Dendrimer Bioconjugates: Synthesis and Applications
Chemistry of Bioconjugates: Synthesis, Characterization, and Biomedical Applications
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© 2014 by John Wiley & Sons, Inc. All rights reserved. This chapter explores how bioconjugation chemistry can be used to covalently attach biologically relevant molecules to dendrimers. It also explores how the specific conjugation chemistries are determined based on the application, the chemical functionalities available on the molecules of interest and those on the dendrimer's focal point or periphery. First, the chapter discusses the conjugation of drug molecules. This is followed by carbohydrates, imaging agents, oligonucleotides, and peptides/proteins. The impact of the conjugation chemistry on the biological properties of the resulting molecules is illustrated through selected examples. Among the currently studied drug delivery systems, dendrimers have emerged as an attractive class of materials, mainly because of their well-defined structures. Doxorubicin (DOX) is a chemotherapeutic commonly used in the treatment of hematological malignancies. Deoxyribonucleic acid (DNA) is a polymer composed of a sequence of nucleotide repeat units that provide a sugar- phosphate backbone and pendant nucleobases.