Bone and Joint Institute

Title

A top-notch dilemma: The complex role of NOTCH signaling in osteoarthritis

Document Type

Article

Publication Date

7-21-2015

Journal

Science Signaling

Volume

8

Issue

386

URL with Digital Object Identifier

10.1126/scisignal.aac7862

Abstract

A study by Liu et al. in the current issue of Science Signaling explores the complex dual role of NOTCH in the etiology of osteoarthritis by comparing gain-offunction mouse models representing aberrant pathological signaling and transient physiological signaling.

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