Bone and Joint Institute

Title

Molecular and histological analysis of a new rat model of experimental knee osteoarthritis

Document Type

Conference Proceeding

Publication Date

1-1-2007

Journal

Annals of the New York Academy of Sciences

First Page

165

Last Page

174

URL with Digital Object Identifier

10.1196/annals.1402.022

Abstract

Articular cartilage degeneration is the most consistently observed feature of osteoarthritis (OA). Animal and human studies have shown that various forms of exercise influence the course of the disease in different ways. In addition, early changes in articular cartilage that influence the progression of OA, such as the expression of cytokines, require further investigation. We have used a surgically induced experimental model of knee OA to address these questions. Here, we discuss our recent studies investigating the effects of an exercise paradigm in surgically induced OA, which determined that the destabilized knee joint is susceptible to enhanced degeneration when subjected to low-intensity, low-impact exercise. Further, we investigated early global changes in gene expression in articular chondrocytes from degenerating cartilage. Identified candidate genes including genes involved in chemokine, endothelin, and transforming growth factor-α signaling are discussed in the context of articular cartilage degeneration in early OA. © 2007 New York Academy of Sciences.

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