Letter to the Editor
Journal of Magnetic Resonance Imaging
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Alpha-1 antitrypsin deficiency (AATD) leads to disabling chronic obstructive pulmonary disease (COPD). Current therapy aimed at slowing lung disease progression includes exogenous alpha-1 antitrypsin augmentation therapy, but there are few potential new treatments under development. Currently used measurements of AATD-related emphysema include the forced expiratory volume in 1 second (FEV1) and the diffusing capacity of carbon monoxide (DLCO); both are relatively insensitive to therapy, although computed tomography (CT) lung density measurements have been shown to worsen more slowly in treated patients.
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This is the peer reviewed version of the following article: A. Westcott, D.P.I. Capaldi, A. Ouriadov, D.G. McCormack & G Parraga. (2018). Hyperpolarized 3He MRI ventilatory apparent diffusion coefficient of alpha-1 antitrypsin deficiency, 49(1): 311-313, which has been published in final form at https://doi.org/10.1002/jmri.26202. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.