Faculty
Physics and Astronomy
Supervisor Name
Eugene Wong
Keywords
Glioblastoma, Glioma, Cancer, IMT, Electrotherapy, Optimization
Description
Intratumoral modulation therapy (IMT) is a novel electrotherapy used to treat brain cancer tumours using electric fields applied directly to the tumours through implanted electrodes. Previous research has validated IMT's effectiveness and provided computer-simulated optimizations for IMT electric fields. This work validates these computer optimizations in-vitro, using a PCB construct to deliver electric fields, and bioluminescence imaging to assess cell viability.
We found electric field strength to correlate with cell viability, and found that rotating (phase-shifted) electric fields did not produce significant improvements in IMT efficacy. Future work will investigate different IMT frequencies and other parameters, while providing biological replicates to strengthen our results.
Acknowledgements
I would like to thank the Hebb lab, including Dr. Matthew Hebb, Hu Xu, and Mila Uzelac; additionally, I should thank the physics machine shop, including Paul Christians and Brian D Dalrymple. Special thanks go to Dr. Eugene Wong, Erin Iredale, and the USRI program!
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License
Document Type
Poster
Included in
Analytical, Diagnostic and Therapeutic Techniques and Equipment Commons, Medical Biophysics Commons, Neurosciences Commons
In-vitro Validation of Intratumoral Modulation Therapy for Glioblastoma
Intratumoral modulation therapy (IMT) is a novel electrotherapy used to treat brain cancer tumours using electric fields applied directly to the tumours through implanted electrodes. Previous research has validated IMT's effectiveness and provided computer-simulated optimizations for IMT electric fields. This work validates these computer optimizations in-vitro, using a PCB construct to deliver electric fields, and bioluminescence imaging to assess cell viability.
We found electric field strength to correlate with cell viability, and found that rotating (phase-shifted) electric fields did not produce significant improvements in IMT efficacy. Future work will investigate different IMT frequencies and other parameters, while providing biological replicates to strengthen our results.