Physiology and Pharmacology Publications
Document Type
Review
Publication Date
Winter 12-1-2017
Journal
Nutrition Reviews
First Page
1
Last Page
20
URL with Digital Object Identifier
10.1093/nutrit/nux053
Abstract
Epidemiologic and clinical research has provided a large body of evidence supporting the developmental origins of health and disease (DOHaD), but there has been a relative dearth of mechanistic studies in humans due to the complexity of working with large, longitudinal cohorts. Nonetheless, animal models of undernutrition have provided substantial evidence for the potential epigenetic, metabolic, and endocrine mechanisms behind DOHaD. Furthermore, recent research has explored the interaction between the environment and the gastrointestinal system by investigating how the gut microbial ecology may impact the capacity for nutrient processing and absorption in a manner that may limit growth. This review presents a summary of current research that supports the concept of DOHaD, as well as potential mechanisms and interactions that explain how nutrition in utero and during early childhood influences lifelong health.
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Medical Physiology Commons, Pharmacy and Pharmaceutical Sciences Commons, Reproductive and Urinary Physiology Commons