Paediatrics Publications

Title

Cytokine Array Comparisons of Plasma from Cycling Fertile Women on Cycle Day 5 and Ovulation

Document Type

Article

Publication Date

9-2009

Journal

American Journal of Reproductive Immunology

Volume

62

Issue

3

First Page

158

Last Page

164

URL with Digital Object Identifier

10.1111/j.1600-0897.2009.00725.x

Abstract

PROBLEM: To identify plasma immuno-regulatory molecules up or down regulated between the follicular phase and ovulation of the human menstrual cycle.

METHOD OF STUDY: RayBio cytokine arrays were used to screen 174 immuno-regulatory molecules in plasma collected during the follicular phase at menstrual cycle day 5 and at ovulation from five healthy, non-smoking, fertile women of reproductive age not using hormonal contraception.

RESULTS: A total of 23 differentially expressed molecules were found: 10 molecules were differentially up-regulated and 13 down-regulated at ovulation compared with that at the follicular phase (alpha = 0.05, false discovery rate of 0.45).

CONCLUSION: Circulating immuno-regulatory molecules fluctuate over the menstrual cycle in healthy women. The combination of differentially expressed molecules suggests roles in cyclical regulation of angiogenesis and immune cell trafficking.