Title

Differential Signaling through the T Cell Receptor: From Biochemistry to Transplantation Tolerance

Document Type

Article

Publication Date

1998

Journal

Histology and Histopathology

Volume

13

Issue

1

First Page

221

Last Page

229

Abstract

Recent advances in our understanding of the structural nature of T cell activation and signal transduction from the T cell receptor for antigen make possible the development of new tolerogenic strategies. Here, we summarize the evidence supporting a critical role for the co-receptor molecule (CD4 or CD8) and CD45 in determining the pattern of T cell receptor-mediated signaling. The consequences of this differential signaling can range from T cell proliferation and cytokine production to the establishment of a state of proliferative unresponsiveness known as T cell anergy. Inducing T cell anergy can be an alternative approach for the establishment of transplantation tolerance.