Nicotinamide Riboside and the Aortic Response to Angiotensin II Infusion in Mice

Sina A. Ghoreishi, The University of Western Ontario

Abstract

Damage to vascular cells of the aorta drives vascular dysfunction and disease. Nicotinamide adenine dinucleotide (NAD⁺) is a cellular metabolite critical to cellular health, but NAD⁺ levels decline during oxidative insults and aging. The NAD⁺ precursor, nicotinamide riboside (NR) can augment NAD⁺ levels. Herein, I determined whether orally administrated NR could protect the aorta of middle-aged mice from acute and sustained angiotensin II (Ang II) infusion-induced damage. I demonstrate that orally administered NR can protect the aorta from damage imposed by Ang II.