Electronic Thesis and Dissertation Repository

Degree

Master of Science

Program

Surgery

Supervisor(s)

Dr. Hassan Razvi

Abstract

Several recent studies have assessed the use of biomarkers of Acute Kidney Injury (AKI), but the information among patients with stone disease and those with obstructive uropathy is limited. For this reason, we conducted a prospective cohort study to determine the urinary levels of KIM-1, Total and Monomeric NGAL in patients with hydronephrosis secondary to renal stone disease, congenital ureteropelvic junction obstruction or ureteral stricture, and in a group of healthy controls in our health care center. Urinary biomarker concentrations were evaluated before and after surgical treatment. Patients with hydronephrosis showed significantly higher baseline levels of KIM-1 compared to those patients without hydronephrosis. KIM-1 was the only urinary biomarker significantly affected by the presence of hydronephrosis. Total and Monomeric NGAL correlated with the presence of leukocyturia. Our results show that KIM-1 is a promising biomarker of subclinical AKI associated with hydronephrosis in urological patients.


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