Potential Therapeutic Role of Hydrogen Sulfide-Releasing Molecule GYY4137 in a Rat Model of Acute Compartment Syndrome.

Author

Moustafa Haddara, The University of Western OntarioFollow

Degree

Master of Science

Program

Surgery

Supervisor

Dr. Abdel-Rahman Lawendy

Abstract

Acute limb compartment syndrome (ACS) causes a unique form of limb ischaemia, which induces intense inflammatory response resulting in microcirculatory dysfunction, neutrophil activation and cell injury. Increased intracompartmental pressure is the hallmark of ACS. Decompression by fasciotomy is the gold standard treatment. While fasciotomy saves the limb from ischaemic threat, paradoxically, it causes further damage to the muscle by reperfusion injury. In addition, it does not address the inflammatory element purported to increase the tissue injury in ACS.

Recent evidence suggests that hydrogen sulfide (H₂S) can mitigate the damage associated with ischaemia-reperfusion injury. The purpose of this thesis was to examine the value of H₂S treatment in a rat model of ACS, using GYY4137 as H₂S-releasing molecule. We have demonstrated significant cytoprotective role of H₂S on the skeletal muscle following ACS.

These results suggest a potential therapeutic value of H₂S as an adjunctive to fasciotomy, for patients suffering ACS.

Recommended Citation

Haddara, Moustafa, "Potential Therapeutic Role of Hydrogen Sulfide-Releasing Molecule GYY4137 in a Rat Model of Acute Compartment Syndrome." (2015). Electronic Thesis and Dissertation Repository. 3027.
https://ir.lib.uwo.ca/etd/3027