Location of Thesis Examination
Room K116 Kresge Building
Master of Science
Epidemiology and Biostatistics
Dr. Amit Garg
Delay of Publication
Older adults are frequently prescribed atypical antipsychotic drugs and may be at a risk for kidney-related adverse events. This population-based retrospective cohort study examined the 90-day risk of acute kidney injury (AKI) and the potential reasons for AKI in 96,471 matched pairs of older adults who received and who did not receive a new atypical antipsychotic drug prescription from 2003 to 2011 in Ontario. Atypical antipsychotic drug use was associated with a higher risk of hospitalization with AKI (relative risk (RR) 2.06 [95% confidence interval (CI) 1.85–2.29]). The drug use was also associated with potential reasons for AKI including hypotension (RR 2.16 [95% CI 1.81–2.57]), acute urinary retention (RR 2.15 [95% CI 1.78–2.60]), and neuroleptic malignant syndrome/rhabdomyolysis (RR 1.44 [95% CI 1.06–1.96]). Residual confounding is unlikely to explain the observed associations entirely. This knowledge informs prescribing practice and may help identify a drug-induced reason for AKI.
Hwang, Yoseob Joseph, "Atypical antipsychotic drugs and the risk of acute kidney injury: A population-based cohort study" (2013). University of Western Ontario - Electronic Thesis and Dissertation Repository. Paper 1409.
Available for download on Friday, June 19, 2015