University of Western Ontario - Electronic Thesis and Dissertation Repository

Location of Thesis Examination

Room K116 Kresge Building


Master of Science


Epidemiology and Biostatistics


Dr. Amit Garg

Delay of Publication



Older adults are frequently prescribed atypical antipsychotic drugs and may be at a risk for kidney-related adverse events. This population-based retrospective cohort study examined the 90-day risk of acute kidney injury (AKI) and the potential reasons for AKI in 96,471 matched pairs of older adults who received and who did not receive a new atypical antipsychotic drug prescription from 2003 to 2011 in Ontario. Atypical antipsychotic drug use was associated with a higher risk of hospitalization with AKI (relative risk (RR) 2.06 [95% confidence interval (CI) 1.85–2.29]). The drug use was also associated with potential reasons for AKI including hypotension (RR 2.16 [95% CI 1.81–2.57]), acute urinary retention (RR 2.15 [95% CI 1.78–2.60]), and neuroleptic malignant syndrome/rhabdomyolysis (RR 1.44 [95% CI 1.06–1.96]). Residual confounding is unlikely to explain the observed associations entirely. This knowledge informs prescribing practice and may help identify a drug-induced reason for AKI.

Available for download on Friday, June 19, 2015