Date of Award

2008

Degree Type

Thesis

Degree Name

Master of Science

Program

Epidemiology and Biostatistics

Supervisor

Dr. M. Karen Campbell

Second Advisor

Dr. Susan E. Evers

Third Advisor

Dr. William R. Avison

Abstract

BACKGROUND: Prenatal depression is a significant public health concern. OBJECTIVES: To contextualize the roles of zinc intake, psychosocial stress and baseline sociodemographic factors, as they inter-relate in the development of depressive symptoms, in a cohort of pregnant women from London (ON). HYPOTHESES: 1) Psychosocial stress serves as a partial mediator between baseline sociodemographic factors and zinc intake; 2) Zinc intake serves as a partial mediator between baseline sociodemographic factors and the development of depressive symptoms, and between psychosocial stress and the development of depressive symptoms. METHODS: Data were from the Prenatal Health Project. Regression methods were used. Baron and Kenny criteria were applied to test mediation. RESULTS AND CONCLUSIONS: Social disadvantage, higher psychosocial stress, and lower zinc intake were associated with increased depressive symptoms. None of the hypotheses on mediation met the Baron and Kenny criteria. However, subsequent analyses suggested that zinc intake functioned instead as a moderator between stress and depressive symptoms.

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