Title

Integrating behavioural, imaging and transcriptional profiling to discover the impact of midlife stress in Alzheimer's disease

Authors and Researchers

BrainsCAN , Western University
Tim Bussey, Western University
Flavio Beraldo, Western University
Chakravarty Maller, McGill University
Rosemary Bagot, McGill University
Sylvain Williams, McGill University
Claudia Kleinman, McGill UniversityFollow

Files

Description

We will be integrating this cognitive assessment with imaging of brain structure and function to understand the mechanisms by which a risk factor, in this case modifiable life stress, influences Alzheimer's disease-related decline. The resultant data will be integrated and disseminated using a new open-access neuroinformatics platform developed at Western (MouseBytes.ca), which will become a unique resource for open science investigations and set the standard for sharing of behavioural data across the world.

Publication Date

2018

Publisher

BrainsCAN

City

London

Keywords

Alzheimer's disease, MRI, Touchscreens, Memory

Disciplines

Neurosciences

Funding

Funding Program

McGill-Western Collaboration Grant

Additional BrainsCAN Support

Rodent Cognition Core

Notes

Western Faculty, Group or Institution

Department of Physiology & Pharmacology, Schulich School of Medicine & Dentistry;
Robarts Research Institute

McGill Faculty, Group or Institution

Department of Psychiatry, Faculty of Medicine

Creative Commons License

This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.