Title

Relating functional and structural signatures of Parkinson’s disease to changes in dopamine signalling: A PET/fMRI study

Authors and Researchers

BrainsCAN . Western University
Penny MacDonald, Western University
Udunna Anazodo, Lawson Health Research Institute
Justin Hicks, Lawson Health Research Institute
Frank Prato, Lawson Health Research Institute
Alain Dagher, McGill UniversityFollow

Files

Description

Cognitive impairments in early Parkinson's disease are known to be linked to complex changes in the dopamine system within the brain. For example, dopamine-producing neurons in one key region of the brain are significantly degenerated, but those in another are spared. Dopamine-replacement therapy (DRT) has been pursued and it has produced significant improvements in certain cognitive functions - unfortunately it also produced significant impairments in others.

Publication Date

2018

Publisher

BrainsCAN

City

London

Keywords

fMRI, MRI, Parkinson's disease

Disciplines

Neurosciences

Funding

Funding Program

BrainsCAN Accelerator Grant: Stimulus

Additional BrainsCAN Support

Imaging Core

Notes

Western Faculty, Group or Institution

Department of Clinical Neurological Sciences, Schulich School of Medicine & Dentistry

Creative Commons License

This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.