This poster discusses the development of a multi-detector computed tomography (MDCT) scanning protocol for dry bone skulls, using a Toshiba Aquilion 64-slice scanner at Quinnipiac University, in North Haven, Connecticut. Unfortunately, for individuals working in paleoimaging, the preset image manipulation factors have been developed for hydrated living tissues. Three likely preset protocols were selected as the initial starting place for the dry bone study in preparation for a potential large sample scanning session of skulls from Peabody Museum of Natural History at Yale University. Each protocol had specific raw data acquisition parameters and algorithm, mathematical manipulations of the raw data, intended to produce a particular effect on the resulting displayed images such as edge enhancement or beam hardening correction. The effects of these subtle data manipulations will be discussed and demonstrated. Finally, although the protocol was developed on a Toshiba unit, the manipulation factors presented can be employed as, at least a starting point for the optimization of image quality while reducing the magnitude of data collected from the scanners of other manufacturers.