Title

Metabolomics as a clinical testing method for the diagnosis of vaginal dysbiosis

Document Type

Conference Proceeding

Publication Date

8-1-2018

Journal

American Journal of Reproductive Immunology

URL with Digital Object Identifier

10.1111/aji.12979

Abstract

© 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd Microbes play an important role in vaginal health, with lactobacilli a particularly abundant species. When dysbiosis occurs, the tools to determine whether it is a condition such as bacterial vaginosis, and whether it warrants antibiotic treatment, are currently suboptimal. We propose that standardization and implementation of an affordable metabolomics-based diagnostic technique could reduce instances of false positives, stress associated with misdiagnosis, and potentially save time and money. Basing diagnosis on the detection of pH elevated above 4.5 and specific polyamines could provide a better method to assist a physician determine whether treatment is warranted.

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