Title of Research Output

Bismuth Binding in Human Metallothionein

Faculty

Science

Supervisor Name

Martin Stillman

Keywords

Bismuth, Metallothionein, Mass-Spectrometry, Pharmaceuticals, UV-Visible Absorption

Description

Bismuth metal is one of the least toxic heavy metals for humans. It is used in a wide variety of applications including organic synthesis, cosmetics and pharmaceutical applications. In biomedicine, bismuth is a therapeutic metal used in metallodrugs such as Pepto Bismol for its antimicrobial and antibacterial properties. Metallothionein (MT) is a cysteine rich protein found in the liver, kidneys, brain and central nervous system. MT can bind a variety of metals including essential metals such as zinc and copper. This research investigates the binding pathway of Bi[EDTA]- with fully metallated Zn7MT by using mass-spectrometry and UV-vis absorption.

Acknowledgements

Thank you to Dr. Martin Stillman, the Stillman Bioinorganic Group, the Western USRI Program, and the Faculty of Science for their support.

Creative Commons License

Creative Commons Attribution-Noncommercial 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License

Document Type

Poster

Share

COinS
 

Bismuth Binding in Human Metallothionein

Bismuth metal is one of the least toxic heavy metals for humans. It is used in a wide variety of applications including organic synthesis, cosmetics and pharmaceutical applications. In biomedicine, bismuth is a therapeutic metal used in metallodrugs such as Pepto Bismol for its antimicrobial and antibacterial properties. Metallothionein (MT) is a cysteine rich protein found in the liver, kidneys, brain and central nervous system. MT can bind a variety of metals including essential metals such as zinc and copper. This research investigates the binding pathway of Bi[EDTA]- with fully metallated Zn7MT by using mass-spectrometry and UV-vis absorption.

 

To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.