Surgery Publications
Title
Molecular Mechanisms and Treatment Strategies for Dupuytren's Disease
Document Type
Article
Publication Date
9-7-2010
Journal
Therapeutics and Clinical Risk Management
Volume
6
First Page
383
Last Page
390
URL with Digital Object Identifier
http://dx.doi.org/10.2147/TCRM.S9165
Abstract
Dupuytren's disease (DD) is a common disease of the hand and is characterized by thickening of the palmar fascia and formation of tight collagenous disease cords. At present, the disease is incurable and the molecular pathophysiology of DD is unknown. Surgery remains the most commonly used treatment for DD, but this requires extensive postoperative therapy and is associated with high rates of recurrence. Over the past decades, more indepth exploration of the molecular basis of DD has raised the hopes of developing new treatment modalities. This paper reviews the clinical presentation and molecular pathophysiology of this disease, as well as current and emerging treatment. It also explores the implications of new findings in the laboratory for future treatment.
