Physiology and Pharmacology Publications
Document Type
Article
Publication Date
3-20-2025
Journal
Reproduction
Volume
169
Issue
5
First Page
e240369
URL with Digital Object Identifier
https://doi.org/10.1530/REP-24-0369
Abstract
In brief: This review article summarizes the effects of pre- or peri-conceptual exposure to cannabinoids on female and male reproductive function, along with pregnancy outcomes from 2014 to 2024. In particular, it addresses the gaps in knowledge regarding the specific contributions of the major constituents of cannabis, THC and CBD, on reproduction. Abstract: With increased use of cannabis worldwide, especially in our young adult population, there is a great impetus to understand the impact of cannabis and its constituents (i.e. THC and CBD) on pregnancy, fetal outcomes and male and female reproductive function. This review assessed the current evidence (2014–2024) regarding the effects of cannabinoids on reproductive function (male, female and pregnancy) in animal and human studies. In particular, preor periconceptual exposure to cannabinoids were assessed to determine their effects across the lifespan along with transgenerational effects. From the outcomes of this review, we conclude there is a greater need for future preclinical and clinical studies to assess how various routes of cannabinoid exposure along with differing mixtures of cannabinoid constituents may interact to impede reproductive health. Collectively, the outcomes of these studies are important to clinicians and regulatory agencies in the context of functional evidence to support policy and decision-making regarding the safety of cannabis use. Keywords: reproductive function; ovary; placenta; sperm; cannabinoids
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Citation of this paper:
Cameron, Reese S, Genevieve A Perono, Christian D Natale, James J Petrik, Alison C Holloway, and Daniel B Hardy. "The impact of cannabinoids on reproductive function", Reproduction 169, 5 (2025), e240369, accessed Apr 8, 2025, https://doi.org/10.1530/REP-24-0369
Notes
https://doi.org/10.1530/REP-24-0369
Reese S Cameron - McMaster University
Genevieve A Perono - McMaster University
Christian D Natale - Western University
James J Petrik - University of Guelph
Alison C Holloway - McMaster University
Daniel B Hardy - Western University