An Open Resource for Non-human Primate Optogenetics

Authors

Sébastien Tremblay, University of Pennsylvania
Leah Acker, McGovern Institute
Arash Afraz, National Institute of Mental Health (NIMH)
Daniel L. Albaugh, Emory University
Hidetoshi Amita, National Eye Institute (NEI)
Ariana R. Andrei, University of Texas Health Science Center at Houston
Alessandra Angelucci, The University of Utah
Amir Aschner, Albert Einstein College of Medicine of Yeshiva University
Puiu F. Balan, KU Leuven
Michele A. Basso, University of California, Los Angeles
Giacomo Benvenuti, The University of Texas at Austin
Martin O. Bohlen, Duke University
Michael J. Caiola, Emory University
Roberto Calcedo, University of Pennsylvania
James Cavanaugh, National Eye Institute (NEI)
Yuzhi Chen, The University of Texas at Austin
Spencer Chen, The University of Texas at Austin
Mykyta M. Chernov, Oregon Health & Science University
Andrew M. Clark, The University of Utah
Ji Dai, Shenzhen Institute of Advanced Technology
Samantha R. Debes, University of Texas Health Science Center at Houston
Karl Deisseroth, Stanford University
Robert Desimone, McGovern Institute
Valentin Dragoi, University of Texas Health Science Center at Houston
Seth W. Egger, McGovern Institute
Mark A.G. Eldridge, National Institute of Mental Health (NIMH)
Hala G. El-Nahal, Duke University
Francesco Fabbrini, KU Leuven
Frederick Federer, The University of Utah
Christopher R. Fetsch, Johns Hopkins School of Medicine
Michal G. Fortuna, Deutsches Primatenzentrum
Robert M. Friedman, Oregon Health & Science University

Document Type

Article

Publication Date

12-23-2020

Journal

Neuron

Volume

108

Issue

6

First Page

1075

Last Page

1090.e6

URL with Digital Object Identifier

10.1016/j.neuron.2020.09.027

Abstract

© 2020 Elsevier Inc. Optogenetics has revolutionized neuroscience in small laboratory animals, but its effect on animal models more closely related to humans, such as non-human primates (NHPs), has been mixed. To make evidence-based decisions in primate optogenetics, the scientific community would benefit from a centralized database listing all attempts, successful and unsuccessful, of using optogenetics in the primate brain. We contacted members of the community to ask for their contributions to an open science initiative. As of this writing, 45 laboratories around the world contributed more than 1,000 injection experiments, including precise details regarding their methods and outcomes. Of those entries, more than half had not been published. The resource is free for everyone to consult and contribute to on the Open Science Framework website. Here we review some of the insights from this initial release of the database and discuss methodological considerations to improve the success of optogenetic experiments in NHPs.