Physiology and Pharmacology Theses and Dissertations

 

This collection contains theses and dissertations from the Department of Physiology and Pharmacology, collected from the Scholarship@Western Electronic Thesis and Dissertation Repository

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Theses/Dissertations from 2022

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Collagen IV-β1Integrin Regulation of Exocytotic Machinery in Pancreatic Beta-Cell Insulin Secretion, Malina Barillaro

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Biomechanical Loading as a Driver of Synovial Neovascularization and Microvascular Dysfunction in Knee Osteoarthritis, Mckenzie Carter

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Impaired Efferocytosis in Knee Osteoarthritis, Luigi M. Del Sordo

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The Impact of Excess Nutrients, Fatty Acids or Glucose, on BeWo Placental Trophoblast Metabolic Function, Zachary JW Easton

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The Hydrophobic Residues in Amino Terminal Domains of Cx46 and Cx50 are Important for their Gap Junction Channel Ion Permeation and Gating, Roa'a Jaradat

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The Effect of OATP2B1-Mediated Statin Transport on Beta Cell Dysfunction, Jihoon Kwon

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The Arg76 Residue of Cx50, Cx43 and Cx45 is Important for the Formation of Functional Gap Junction Channels, Tianhe Li

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The Molecular Mechanisms of Hepatic Mitochondrial Dysfunction in Growth-Restricted Offspring with Hyperlipidemia, Shelby L. Oke

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Tracing the Fate of Cytokeratin 19+ Cells During Beta Cell Regeneration Stimulated by Multipotent Stromal Cell-Secreted Effectors, Nazihah Rasiwala

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Exploring the effects of spinal cord stimulation for freezing of gait in parkinsonian patients, Olivia Samotus

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The Effects Of Autophagy And Proteasomes On TGFβ Signalling And EMT, Charles Brandon Trelford

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Roles of STIM1 Cys56 and Cys49 in Store-Operated Ca2+ Entry and Cardiac Rhythm during Myocardial Ischemia and Reperfusion, Kaiyuan Wang

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Absence of Enhancer of Zeste Homolog 2 Promotes the Progression of KRAS-Driven Pancreatic Ductal Adenocarcinoma, Xiaoyi Wang

Theses/Dissertations from 2021

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Exogenous Surfactant as a Delivery Vehicle for Intrapulmonary Therapeutics, Brandon J. Baer

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Maternal Lifelong Western Diet Consumption Impacts Placental and Brain Development in the Term Guinea Pig Fetus, Carlene H. Cihosky

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Characterization and modulatory influence of pyruvate kinase muscle isoforms 1 and 2 within the murine pluripotent continuum, Joshua G. Dierolf

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Fatty Acid Regulation of the Nrf2/Keap1 Pathway During Mouse Preimplantation Embryo Development, Grace Dionne

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Inwardly Rectifying Potassium Channels: Regulators of Myogenic Tone in Cerebrovascular Smooth Muscle, Jacob Fletcher

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Investigating the role of interleukin-15 in post-traumatic osteoarthritis, Ermina Hadzic

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Modulation of GABAA Receptor by Neurosteroids and Protein Kinases in Health and Disease, Jaymin Jeong

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Effects of ergothioneine on endothelial cell and macrophage characteristics, and markers of atherosclerosis risk under high lipid conditions, Daniel Lam-Sidun

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Free fatty acid treatment alters autophagy during mouse preimplantation embryo development, Zuleika C. L. Leung

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Creating Tools to Study the Signaling and Function of the Adhesion Family of GPCRs, Victor M. Mirka

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The effects of decellularized adipose tissue constructs on mesenchymal stromal/stem cell phenotype and pro-angiogenic secretory function., Yehia Moharrem

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Uncovering the Structural Basis for Mitochondrial Calcium Uniporter Dominant Negative Beta Subunit (MCUb) Function, Megan L. Noble

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Targeting CCN Proteins in the Treatment of Dermal Fibrosis, Alex Peidl

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Characterizing the structural, biophysical and functional effects of S-Glutathionylation on STIM1 Ca2+ sensing, Christian Michael Sirko

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Effects of Annexin A5 on Endothelial Inflammation Induced by Lipopolysaccharide-Activated Platelets and Extracellular Vesicles, Brent Jeffrey Tschirhart

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Impact of Clinical and Pharmacogenetic Variables on the Risk of Fluoropyrimidine-Related Adverse Events within Ontario, Theodore J. Wigle

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Characterizing the Effects of Pyrroloquinoline Quinone (PQQ) Supplementation on Skeletal Muscle Mitochondrial Function and Myogenesis During Oxidative Stress and IUGR., Allyson J. Wood

Theses/Dissertations from 2020

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Developing a model to assess the contribution of cytokeratin 19-expressing cells during multipotent stromal cell-induced islet regeneration, Brianna Ananthan

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Investigating pathways associated with intervertebral disc degeneration and back pain., Geoffrey J. Kerr

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The Role of Histone Demethylases in Learning and Memory in the Mushroom Body of Drosophila melanogaster, Crystal Keung

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Characterization of Mechanotransduction in Annulus Fibrosus Cells, Min Kyu M. Kim

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The Role of TIMP3 in Microvascular Endothelial Cell-Extracellular Matrix Interaction and Regulation of Microvascular Barrier Function, Nidhi Kulkarni

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The Role of Synovium and Synovial Macrophages in Experimental Post-Traumatic Knee Osteoarthritis, Yue Lai-Zhao

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The Role of Regulator of G Protein Signaling 2 in Inflammatory Cytokine Release in Endotoxemia in Mice, Xin Tong Ma

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Mushroom body-specific gene regulation by the SWI/SNF chromatin remodeling complex, Kevin CJ Nixon

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The Effects of Maternal Delta-9-Tetrahydrocannabinol and Cannabidiol Exposure on Fetal Heart Development in Mice, Gregory Robinson

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Mitogen Inducible Gene-6 in Joint Health and Osteoarthritis, Melina Rodrigues Bellini

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Human Genetic Variation in Na+-Taurocholate Co-transporting Polypeptide (NTCP; SLC10A1) and Targeted Slc10a1 Disruption in Mice: Effects on Bile Acid and Rosuvastatin Transport, Laura E. Russell

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Pan-Cancer Analysis of Telomerase Reverse Transcriptase (TERT) Isoforms, Mathushan Subasri

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Mechanisms of beta-cell deficiency in gestational diabetes and strategies to reverse hyperglycemia, Sandra K. Szlapinski

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Molecular Mechanisms Regulating the Platelet Thrombin Receptor PAR4, Pierre E. Thibeault

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Regulators of Ectopic Calcification in a Mouse Model of DISH: A Multi-Omics Perspective, Matthew A. Veras

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The amino terminal domains of sheep Cx46 or Cx50 determine their gap junction channel open stability and unitary channel conductance, Benny Yue

Theses/Dissertations from 2019

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Absence of Activating Transcription Factor 3 Reduces Severity of Recurrent Pancreatitis and K-RAS Mediated PDAC in Mice, Nawab Azizi

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HEI-OC1 Cochlear Cells as an In Vitro Model to Study the Role of Connexins in Ototoxicity and Hearing Loss, Rianne Beach

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Assessing the structure-function relationships of the apolipoprotein(a) kringle IV sub-type 10 domain, Matthew J. Borrelli

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The Role of Pannexin 1 during Human Adipogenesis in vitro, Jamie Emily Ching

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Apolipoprotein(a) Secretion is Modulated by Sortilin, Proprotein Convertase Subtilisin/Kexin Type 9, and Microsomal Triglyceride Transfer Protein, Justin Clark

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Identification of Human Postnatal Progenitor Cells with Multifaceted Regenerative Functions, Tyler T. Cooper

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Integrin-linked Kinase Modulation of Melanocytic Lineage Cells, Melissa Crawford

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Pregestational Diabetes Induced Congenital Heart Defects and Coronary Artery Malformations; Mechanisms and Preventative Therapies, Anish Engineer

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The Secretory Pathway Calcium ATPase 2C promotes increased cytosolic calcium levels, Melissa Fenech

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Maternal nicotine exposure induces congenital heart defects in the offspring of mice, Elizabeth Greco

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Synthesis and Characterization of American Ginseng Polysaccharides Nanoparticles, Vincent Lee

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Applications of Hair as a Record of Systemic Exposure to Cortisol, Jeffrey Matthew Levine

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Dynamic mechanostimulation of live cells during real-time microscopy, Daniel Lorusso

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Excess NO stabilizes the luminal domain of STIM2 in a Cys-specific manner thereby regulating basal calcium homeostasis and store-operated calcium entry, Matthew Novello

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Effects of Niacin and Vitamin D on Endothelial Cell Angiogenic Function and Vascular Regeneration During Lipotoxicity, Kia Mae Peters

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The role of ATF4 in amyloid-beta-induced neuronal death., Gillian Petroff

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YAP-mediated mechanotransduction promotes fibrotic activity, Michael Racanelli

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The Purification of Human Adult Progenitor Cell Types to Promote Angiogenesis, Stephen E. Sherman

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Mapping and functional characterization of proteolytic cleavage of murine kidney injury molecule-1, Saranga Sriranganathan

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Phenotypic and Metabolic Plasticity In Canine Cellular Reprogramming, Ian C. Tobias

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Oleic Acid Attenuates Palmitic Acid-Induced Impairments in Mouse Blastocyst Development, Maisoon Dafalla Yousif

Theses/Dissertations from 2018

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The Role Of FER Kinase In Human Melanoma Growth and Invasion, Shinthujah Arulanantham

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The Characterization of Cx31 in Keratinocytes and its Link to Erythrokeratodermia Variabilis et Progressiva, Akina Au

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Clinical and Genetic Predictors of Aromatase Inhibitor-Induced Arthralgia, Adrienne Elizabeth Borrie

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The 2β Insert Perturbs Folding, Stability and Hydrophobic Exposure of Stromal Interaction Molecules, Steve Chung

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The Role of Hand1 in the Development of the Lateral Plate Mesoderm in Xenopus, Victoria A. Deveau

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A normalization circuit of attention in primate lateral prefrontal cortex, Lyndon Duong

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The Role of p66Shc in Mouse Blastocyst Development, Nicole A. Edwards

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Expression of Hepatic Cytochrome P450 Drug Metabolizing Enzymes in Diabetes and Diabetic Nephropathy, Cheng Jay Fang

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Clinical And Pharmacogenetic Determinants Of Plasma Factor Xa Inhibitor Systemic Exposure, Markus Gulilat

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Role Of The Dorsal Striatum In Learning and Decision Making, Nole M. Hiebert

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Investigating the Practical and Clinical Effectiveness of Applying Current Steering to Deep Brain Stimulation for Parkinsonian Gait Therapy, Daphne Hui

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The use of current steering during subthalamic deep brain stimulation to alleviate upper limb symptoms of Parkinson's disease, Shabna Iftikar Mohideen

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Effects of Maternal Protein Restriction on the Pulmonary Surfactant System during the Early Life and Adulthood, Reza Khazaee

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Modulation of parathyroid hormone 1 receptor signaling by extracellular nucleotides, Brandon Kim

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Heterotypic Docking Compatibility of Human Connexin 37 with Other Vascular Connexins, Nicholas Kim

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Reactive Oxygen Species and the Regulation of Cerebral Vascular Myogenic Tone, Neil Mazumdar

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Endothelial Glycocalyx Shedding in Pediatric Diabetic Ketoacidosis, Rufina Ning

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A Hierarchical Approach to Assessing the Effects of Exercise on Cognition, Alexandra Pearce

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The Role of Cholinergic Signaling in Cardiac Function, Rachel Reingold

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Investigating the role of pannexin 3 in intervertebral disc health and disease, Meaghan E. Serjeant

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The mitochondrial calcium uniporter regulator 1 (MCUR1) matrix domain is a self-associated multimer sensitive to divalent cations, Naveed Siddiqui

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Effects of G Protein Signalling Modulator 3 on Cellular Signalling, Aneta A. Surmanski

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Behavioural and Anatomical Effects of Unilateral Injection of Botulinum Neurotoxin A in the Entopeduncular Nucleus of a Parkinsonian Rat Model, Adrianna Tsang

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Drug Response And Metabolism In Crohn's Disease, Aze Wilson

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Beta-cell β1 Integrin Deficiency During Second Transition Stage Of Fetal Pancreas Development On Islet Growth, Phyo Win

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The role of TGFβ type III receptor in lung cancer cell migration and invasion, Anthony Ziccarelli

Theses/Dissertations from 2017

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The Potential Role of Cathelicidin Peptides for the Treatment of Lower Respiratory Tract Infections, Brandon John Harrison Banaschewski

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Cardiac repair post-myocardial infarction: Roles of the primary cilium and the long non-coding RNA Malat1, Jessica N. Blom

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Retinoic Acid Pathway Inhibition to Expand Human Hematopoietic Progenitor Cells with Islet Regenerative Capacity, Ruth Elgamal

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Maternal Nutrient Restriction in Pregnant Guinea Pigs and the Impact on Fetal Growth and Brain Development, Andrew Ghaly

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Hepatic Drug Metabolism, Uremic Toxins and Bacterial Composition Over Chronic Kidney Disease Progression, Emily Dee Hartjes

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Synaptic Mechanisms for the Hypothalamic-Pituitary-Adrenal Axis Activation by Prostaglandin E2, Zahra Khazaeipool

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Alternative splicing and extra-telomeric role of telomerase reverse transcriptase isoforms in human embryonic stem cells, Joohwan Kim