Physiology and Pharmacology Theses and Dissertations
This collection contains theses and dissertations from the Department of Physiology and Pharmacology, collected from the Scholarship@Western Electronic Thesis and Dissertation Repository
Theses/Dissertations from 2020
Developing a model to assess the contribution of cytokeratin 19-expressing cells during multipotent stromal cell-induced islet regeneration, Brianna Ananthan
Investigating pathways associated with intervertebral disc degeneration and back pain., Geoffrey J. Kerr
The Role of Histone Demethylases in Learning and Memory in the Mushroom Body of Drosophila melanogaster, Crystal Keung
Characterization of Mechanotransduction in Annulus Fibrosus Cells, Min Kyu M. Kim
The Role of TIMP3 in Microvascular Endothelial Cell-Extracellular Matrix Interaction and Regulation of Microvascular Barrier Function, Nidhi Kulkarni
The Role of Synovium and Synovial Macrophages in Experimental Post-Traumatic Knee Osteoarthritis, Yue Lai-Zhao
The Role of Regulator of G Protein Signaling 2 in Inflammatory Cytokine Release in Endotoxemia in Mice, Xin Tong Ma
Mushroom body-specific gene regulation by the SWI/SNF chromatin remodeling complex, Kevin CJ Nixon
The Effects of Maternal Delta-9-Tetrahydrocannabinol and Cannabidiol Exposure on Fetal Heart Development in Mice, Gregory Robinson
Mitogen Inducible Gene-6 in Joint Health and Osteoarthritis, Melina Rodrigues Bellini
Pan-Cancer Analysis of Telomerase Reverse Transcriptase (TERT) Isoforms, Mathushan Subasri
Mechanisms of beta-cell deficiency in gestational diabetes and strategies to reverse hyperglycemia, Sandra K. Szlapinski
Molecular Mechanisms Regulating the Platelet Thrombin Receptor PAR4, Pierre E. Thibeault
Regulators of Ectopic Calcification in a Mouse Model of DISH: A Multi-Omics Perspective, Matthew A. Veras
Theses/Dissertations from 2019
HEI-OC1 Cochlear Cells as an In Vitro Model to Study the Role of Connexins in Ototoxicity and Hearing Loss, Rianne Beach
Assessing the structure-function relationships of the apolipoprotein(a) kringle IV sub-type 10 domain, Matthew J. Borrelli
The Role of Pannexin 1 during Human Adipogenesis in vitro, Jamie Emily Ching
Identification of Human Postnatal Progenitor Cells with Multifaceted Regenerative Functions, Tyler T. Cooper
Integrin-linked Kinase Modulation of Melanocytic Lineage Cells, Melissa Crawford
Pregestational Diabetes Induced Congenital Heart Defects and Coronary Artery Malformations; Mechanisms and Preventative Therapies, Anish Engineer
The Secretory Pathway Calcium ATPase 2C promotes increased cytosolic calcium levels, Melissa Fenech
Maternal nicotine exposure induces congenital heart defects in the offspring of mice, Elizabeth Greco
Synthesis and Characterization of American Ginseng Polysaccharides Nanoparticles, Vincent Lee
Applications of Hair as a Record of Systemic Exposure to Cortisol, Jeffrey Matthew Levine
Dynamic mechanostimulation of live cells during real-time microscopy, Daniel Lorusso
Excess NO stabilizes the luminal domain of STIM2 in a Cys-specific manner thereby regulating basal calcium homeostasis and store-operated calcium entry, Matthew Novello
Effects of Niacin and Vitamin D on Endothelial Cell Angiogenic Function and Vascular Regeneration During Lipotoxicity, Kia Mae Peters
The role of ATF4 in amyloid-beta-induced neuronal death., Gillian Petroff
YAP-mediated mechanotransduction promotes fibrotic activity, Michael Racanelli
The Purification of Human Adult Progenitor Cell Types to Promote Angiogenesis, Stephen E. Sherman
Mapping and functional characterization of proteolytic cleavage of murine kidney injury molecule-1, Saranga Sriranganathan
Phenotypic and Metabolic Plasticity In Canine Cellular Reprogramming, Ian C. Tobias
Oleic Acid Attenuates Palmitic Acid-Induced Impairments in Mouse Blastocyst Development, Maisoon Dafalla Yousif
Theses/Dissertations from 2018
The Role Of FER Kinase In Human Melanoma Growth and Invasion, Shinthujah Arulanantham
Clinical and Genetic Predictors of Aromatase Inhibitor-Induced Arthralgia, Adrienne Elizabeth Borrie
The 2β Insert Perturbs Folding, Stability and Hydrophobic Exposure of Stromal Interaction Molecules, Steve Chung
The Role of Hand1 in the Development of the Lateral Plate Mesoderm in Xenopus, Victoria A. Deveau
A normalization circuit of attention in primate lateral prefrontal cortex, Lyndon Duong
The Role of p66Shc in Mouse Blastocyst Development, Nicole A. Edwards
Expression of Hepatic Cytochrome P450 Drug Metabolizing Enzymes in Diabetes and Diabetic Nephropathy, Cheng Jay Fang
Clinical And Pharmacogenetic Determinants Of Plasma Factor Xa Inhibitor Systemic Exposure, Markus Gulilat
Role Of The Dorsal Striatum In Learning and Decision Making, Nole M. Hiebert
The use of current steering during subthalamic deep brain stimulation to alleviate upper limb symptoms of Parkinson's disease, Shabna Iftikar Mohideen
Effects of Maternal Protein Restriction on the Pulmonary Surfactant System during the Early Life and Adulthood, Reza Khazaee
Modulation of parathyroid hormone 1 receptor signaling by extracellular nucleotides, Brandon Kim
Heterotypic Docking Compatibility of Human Connexin 37 with Other Vascular Connexins, Nicholas Kim
Reactive Oxygen Species and the Regulation of Cerebral Vascular Myogenic Tone, Neil Mazumdar
Endothelial Glycocalyx Shedding in Pediatric Diabetic Ketoacidosis, Rufina Ning
A Hierarchical Approach to Assessing the Effects of Exercise on Cognition, Alexandra Pearce
The Role of Cholinergic Signaling in Cardiac Function, Rachel Reingold
Investigating the role of pannexin 3 in intervertebral disc health and disease, Meaghan E. Serjeant
The mitochondrial calcium uniporter regulator 1 (MCUR1) matrix domain is a self-associated multimer sensitive to divalent cations, Naveed Siddiqui
Effects of G Protein Signalling Modulator 3 on Cellular Signalling, Aneta A. Surmanski
Behavioural and Anatomical Effects of Unilateral Injection of Botulinum Neurotoxin A in the Entopeduncular Nucleus of a Parkinsonian Rat Model, Adrianna Tsang
Drug Response And Metabolism In Crohn's Disease, Aze Wilson
The role of TGFβ type III receptor in lung cancer cell migration and invasion, Anthony Ziccarelli
Theses/Dissertations from 2017
The Potential Role of Cathelicidin Peptides for the Treatment of Lower Respiratory Tract Infections, Brandon John Harrison Banaschewski
Cardiac repair post-myocardial infarction: Roles of the primary cilium and the long non-coding RNA Malat1, Jessica N. Blom
Retinoic Acid Pathway Inhibition to Expand Human Hematopoietic Progenitor Cells with Islet Regenerative Capacity, Ruth Elgamal
Maternal Nutrient Restriction in Pregnant Guinea Pigs and the Impact on Fetal Growth and Brain Development, Andrew Ghaly
Hepatic Drug Metabolism, Uremic Toxins and Bacterial Composition Over Chronic Kidney Disease Progression, Emily Dee Hartjes
Synaptic Mechanisms for the Hypothalamic-Pituitary-Adrenal Axis Activation by Prostaglandin E2, Zahra Khazaeipool
The Role of OATP-Mediated Statin Transport in Pancreatic Beta Cell Function, Michelle S. Kim
Distinct Roles of GABA(A)R Signaling in the Regulation of Two Human T lymphocyte Lines, Ying Lin
The Metalloproteinase-Dependent Role of TIMPs in Regulation of Pulmonary Microvascular Endothelial Cell Barrier Function During Sepsis, Marcello G. Masciantonio
Effects of Prenatal Bisphenol A Exposure on Adrenal Gland Development and Steroidogenic Function, Samantha Medwid
Pannexins 1 and 3 in Skeletal Health and Osteoarthritis, Paxton M. Moon
The Role of p62/SQSTM1 in TGFβ-dependent EMT and Autophagy, Evelyn Ng
Functional Characteristics of Four Novel Lone Atrial Fibrillation-Linked Connexin40 Mutants, Mahmoud Noureldin
Investigating The Acute Levodopa Response In Early To Advanced Parkinson’s Disease, Marcus M. Pieterman
Liver X Receptor and Retinoid X Receptor in Cartilage Development and Homeostasis, Man-Ger Sun
The Loss Of ATRX Creates Susceptibility To KRAS-Mediated Pancreatic Damage, Claire C. Young
Theses/Dissertations from 2016
Glycosylation on Stromal Interaction Molecule-1 Ca2+ sensing region enhances Store Operated Ca2+ Entry, Yoo Jung Choi
New Insights into Signal Detection of the Effects of Exposures during Pregnancy, Fatma Etwel
PDZ Protein Regulation of β-arrestin Recruitment and GPCR Trafficking, Sarah Gupta
CAL and MAGI PDZ Protein Regulation of CRFR1 and 5-HT2AR Trafficking and Signaling, Maha Mahmoud Hammad
The Effect of AST-120 on Hepatic Metabolism and Transport in Chronic Kidney Disease, Andrew S. Kucey
The Mitochondrial Calcium Uniporter Is Autoregulated by Cation Binding to the β-Grasp-Like Matrix Domain, Samuel K. Lee
Evaluating the role of intestinal transporters in fruit juice-drug interactions, Mandy MJ Li
Evaluation of Food Effects on the Oral Pharmacokinetics of Rosuvastatin, Cheynne C. McLean
The Biophysical Alterations to Pulmonary Surfactant during Lung Injury, Scott D. Milos
Identification Of A Novel Interaction Between Integrin-Linked Kinase And Beta-Arrestin 1, Hannah E. Murphy-Marshman
Corticotropin releasing factor receptor type 1 signaling in epilepsy and traumatic brain injury, V V Chakravarthi Narla
Maternal Nutrient Restriction with Fetal Growth Restriction in Guinea Pigs Impacts Brain Development and Neuroimaging Correlates in Neonatal Offspring, Catherine Nevin
The Role of GABA Signalling in Lung Macrophage Immune Response, Jacob W. Poirier
Insights into the role of connexin26 and connexin30 in skin health, syndromic disease, and cutaneous wound healing, Eric R. Press
Pharmacogenetics of Non-Motor Symptoms in Parkinson's Disease, Brian Robertson
Putative Pore-lining Residues and Intracellular Magnesium Influence Connexin50 Unitary Gap Junction Channel Conductance, Swathy Sudhakar
Beta blocker dialyzability and effectiveness in chronic hemodialysis patients, Alvin Tieu
Signal Transduction Mechanisms Mediating the Regulation of Vascular G Protein-Coupled Receptors, Elena Tutunea-Fatan
A Non-Canonical Role for Choline Acetyltransferase in Chromatin Organization and the Response to Beta-Amyloid, Warren R. Winick-Ng