Physiology and Pharmacology Theses and Dissertations
This collection contains theses and dissertations from the Department of Physiology and Pharmacology, collected from the Scholarship@Western Electronic Thesis and Dissertation Repository
Theses/Dissertations from 2019
HEI-OC1 Cochlear Cells as an In Vitro Model to Study the Role of Connexins in Ototoxicity and Hearing Loss, Rianne Beach
Identification of Human Postnatal Progenitor Cells with Multifaceted Regenerative Functions, Tyler T. Cooper
Pregestational Diabetes Induced Congenital Heart Defects and Coronary Artery Malformations; Mechanisms and Preventative Therapies, Anish Engineer
Maternal nicotine exposure induces congenital heart defects in the offspring of mice, Elizabeth Greco
Synthesis and Characterization of American Ginseng Polysaccharides Nanoparticles, Vincent Lee
Effects of Niacin and Vitamin D on Endothelial Cell Angiogenic Function and Vascular Regeneration During Lipotoxicity, Kia Mae Peters
YAP-mediated mechanotransduction promotes fibrotic activity, Michael Racanelli
The Purification of Human Adult Progenitor Cell Types to Promote Angiogenesis, Stephen E. Sherman
Phenotypic and Metabolic Plasticity In Canine Cellular Reprogramming, Ian C. Tobias
Oleic Acid Attenuates Palmitic Acid-Induced Impairments in Mouse Blastocyst Development, Maisoon Dafalla Yousif
Theses/Dissertations from 2018
The Role Of FER Kinase In Human Melanoma Growth and Invasion, Shinthujah Arulanantham
Clinical and Genetic Predictors of Aromatase Inhibitor-Induced Arthralgia, Adrienne Elizabeth Borrie
The 2β Insert Perturbs Folding, Stability and Hydrophobic Exposure of Stromal Interaction Molecules, Steve Chung
The Role of Hand1 in the Development of the Lateral Plate Mesoderm in Xenopus, Victoria A. Deveau
A normalization circuit of attention in primate lateral prefrontal cortex, Lyndon Duong
The Role of p66Shc in Mouse Blastocyst Development, Nicole A. Edwards
Expression of Hepatic Cytochrome P450 Drug Metabolizing Enzymes in Diabetes and Diabetic Nephropathy, Cheng Jay Fang
Clinical And Pharmacogenetic Determinants Of Plasma Factor Xa Inhibitor Systemic Exposure, Markus Gulilat
Role Of The Dorsal Striatum In Learning and Decision Making, Nole M. Hiebert
The use of current steering during subthalamic deep brain stimulation to alleviate upper limb symptoms of Parkinson's disease, Shabna Iftikar Mohideen
Effects of Maternal Protein Restriction on the Pulmonary Surfactant System during the Early Life and Adulthood, Reza Khazaee
Modulation of parathyroid hormone 1 receptor signaling by extracellular nucleotides, Brandon Kim
Heterotypic Docking Compatibility of Human Connexin 37 with Other Vascular Connexins, Nicholas Kim
Reactive Oxygen Species and the Regulation of Cerebral Vascular Myogenic Tone, Neil Mazumdar
Endothelial Glycocalyx Shedding in Pediatric Diabetic Ketoacidosis, Rufina Ning
A Hierarchical Approach to Assessing the Effects of Exercise on Cognition, Alexandra Pearce
The Role of Cholinergic Signaling in Cardiac Function, Rachel Reingold
Investigating the role of pannexin 3 in intervertebral disc health and disease, Meaghan E. Serjeant
The mitochondrial calcium uniporter regulator 1 (MCUR1) matrix domain is a self-associated multimer sensitive to divalent cations, Naveed Siddiqui
Effects of G Protein Signalling Modulator 3 on Cellular Signalling, Aneta A. Surmanski
Behavioural and Anatomical Effects of Unilateral Injection of Botulinum Neurotoxin A in the Entopeduncular Nucleus of a Parkinsonian Rat Model, Adrianna Tsang
Drug Response And Metabolism In Crohn's Disease, Aze Wilson
The role of TGFβ type III receptor in lung cancer cell migration and invasion, Anthony Ziccarelli
Theses/Dissertations from 2017
The Potential Role of Cathelicidin Peptides for the Treatment of Lower Respiratory Tract Infections, Brandon John Harrison Banaschewski
Cardiac repair post-myocardial infarction: Roles of the primary cilium and the long non-coding RNA Malat1, Jessica N. Blom
Retinoic Acid Pathway Inhibition to Expand Human Hematopoietic Progenitor Cells with Islet Regenerative Capacity, Ruth Elgamal
Maternal Nutrient Restriction in Pregnant Guinea Pigs and the Impact on Fetal Growth and Brain Development, Andrew Ghaly
Hepatic Drug Metabolism, Uremic Toxins and Bacterial Composition Over Chronic Kidney Disease Progression, Emily Dee Hartjes
Synaptic Mechanisms for the Hypothalamic-Pituitary-Adrenal Axis Activation by Prostaglandin E2, Zahra Khazaeipool
The Role of OATP-Mediated Statin Transport in Pancreatic Beta Cell Function, Michelle S. Kim
Distinct Roles of GABA(A)R Signaling in the Regulation of Two Human T lymphocyte Lines, Ying Lin
The Metalloproteinase-Dependent Role of TIMPs in Regulation of Pulmonary Microvascular Endothelial Cell Barrier Function During Sepsis, Marcello G. Masciantonio
Effects of Prenatal Bisphenol A Exposure on Adrenal Gland Development and Steroidogenic Function, Samantha Medwid
Pannexins 1 and 3 in Skeletal Health and Osteoarthritis, Paxton M. Moon
The Role of p62/SQSTM1 in TGFβ-dependent EMT and Autophagy, Evelyn Ng
Functional Characteristics of Four Novel Lone Atrial Fibrillation-Linked Connexin40 Mutants, Mahmoud Noureldin
Investigating The Acute Levodopa Response In Early To Advanced Parkinson’s Disease, Marcus M. Pieterman
Liver X Receptor and Retinoid X Receptor in Cartilage Development and Homeostasis, Man-Ger Sun
The Loss Of ATRX Creates Susceptibility To KRAS-Mediated Pancreatic Damage, Claire C. Young
Theses/Dissertations from 2016
Glycosylation on Stromal Interaction Molecule-1 Ca2+ sensing region enhances Store Operated Ca2+ Entry, Yoo Jung Choi
New Insights into Signal Detection of the Effects of Exposures during Pregnancy, Fatma Etwel
PDZ Protein Regulation of β-arrestin Recruitment and GPCR Trafficking, Sarah Gupta
CAL and MAGI PDZ Protein Regulation of CRFR1 and 5-HT2AR Trafficking and Signaling, Maha Mahmoud Hammad
The Effect of AST-120 on Hepatic Metabolism and Transport in Chronic Kidney Disease, Andrew S. Kucey
The Mitochondrial Calcium Uniporter Is Autoregulated by Cation Binding to the β-Grasp-Like Matrix Domain, Samuel K. Lee
Evaluating the role of intestinal transporters in fruit juice-drug interactions, Mandy MJ Li
Evaluation of Food Effects on the Oral Pharmacokinetics of Rosuvastatin, Cheynne C. McLean
The Biophysical Alterations to Pulmonary Surfactant during Lung Injury, Scott D. Milos
Identification Of A Novel Interaction Between Integrin-Linked Kinase And Beta-Arrestin 1, Hannah E. Murphy-Marshman
Corticotropin releasing factor receptor type 1 signaling in epilepsy and traumatic brain injury, V V Chakravarthi Narla
Maternal Nutrient Restriction with Fetal Growth Restriction in Guinea Pigs Impacts Brain Development and Neuroimaging Correlates in Neonatal Offspring, Catherine Nevin
The Role of GABA Signalling in Lung Macrophage Immune Response, Jacob W. Poirier
Insights into the role of connexin26 and connexin30 in skin health, syndromic disease, and cutaneous wound healing, Eric R. Press
Pharmacogenetics of Non-Motor Symptoms in Parkinson's Disease, Brian Robertson
Putative Pore-lining Residues and Intracellular Magnesium Influence Connexin50 Unitary Gap Junction Channel Conductance, Swathy Sudhakar
Beta blocker dialyzability and effectiveness in chronic hemodialysis patients, Alvin Tieu
Signal Transduction Mechanisms Mediating the Regulation of Vascular G Protein-Coupled Receptors, Elena Tutunea-Fatan
A Non-Canonical Role for Choline Acetyltransferase in Chromatin Organization and the Response to Beta-Amyloid, Warren R. Winick-Ng
Theses/Dissertations from 2015
Septic Murine Pulmonary Microvascular Endothelial Cell Barrier Dysfunction is Regulated by Tissue Inhibitor of Metalloproteinases 3, Valerie Arpino
KISS1R Signaling Promotes Breast Cancer Drug Resistance, Alexandra J. Blake
Studies into the Regulation of FTO by Angiotensin II in Cardiomyocyte Hypertrophy, Kwame N. Boakye-Ansah
Atrial Fibrillation Promotion by Intermittent Hypoxia in the Rat, Sara Bober
TIMP3 Regulation of Macrophage Activation and Apoptosis, Michael S. Brock
The Rho GTPases Rac1, Cdc42, and RhoA Regulate APP Transport to Lysosomes and Aβ Production, Justin K. Chiu .
Cardioprotective Role of the Cholinergic System, Mouhamed Dakroub
Skeletal Muscle Lipid Metabolism and Markers of Insulin Resistance in Young Male Low Birth Weight Offspring in Combination With a Postnatal Western Diet, Kristyn Pamela Dunlop
Maternal Nutrient Restriction in Pregnant Guinea Pigs Impacts Fetal-Placental Growth and Oxygenation, Alexander Elias
Inhibition of elongation factor 1A-1 activity and hepatic lipotoxicity, Alexandra Margaret Anne Hetherington
Engineered connexin40 variants increased docking and function of heterotypic connexin40/connexin43 gap junction channels, Arjewan Jassim
Modulation of synaptic plasticity by hippocampal theta rhythm, Clayton Law
Cardiomyocyte Polarity and Embryonic Heart Development: Role of Rac1, Carmen Leung
Fibulin-3 Promotes Triple Negative Breast Cancer Cell Invasion, Michelle M. Noonan
The CTCF Chromatin Organizer is Required for Hindlimb Development, Katherine L. Rabicki
The Role of Connexins and Pannexins in Mammary Gland Development and Tumorigenesis, Michael K. G. Stewart
Stability and Activity of Naturally Occurring RGS2 Variants, Patrick Stockwell
The Role of Shroom3 in Kidney Development, Alexandra Sull
Novel Video Imaging to Examine Cardiac Function in Xenopus Embryos, Judith Sull
Pathophysiologic Mechanisms of Immune-mediated Drug Hypersensitivity Reactions to Sulfonamides, Elham A. Sultan
Mechanisms of ATF4-mediated neuronal apoptosis, Patrick Swan
Intracellular Trafficking Governs the Processing of the Amyloid Precursor Protein and the Secretion of Beta-Amyloid, Joshua Hoi Ki Tam
Investigating The Mechanism Of Ectopic Mineralization In A Mouse Model Of Diffuse Idiopathic Skeletal Hyperostosis (DISH), Neil A. Tenn
Investigating the Fibroblastic Origin of Skin-Derived Precursors and the Role Of CCN2 as a Mediator of Myofibroblastic Differentiation, Matthew Tsang