Physiology and Pharmacology Theses and Dissertations

 

This collection contains theses and dissertations from the Department of Physiology and Pharmacology, collected from the Scholarship@Western Electronic Thesis and Dissertation Repository

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Theses/Dissertations from 2019

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Absence of Activating Transcription Factor 3 Reduces Severity of Recurrent Pancreatitis and K-RAS Mediated PDAC in Mice, Nawab Azizi

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HEI-OC1 Cochlear Cells as an In Vitro Model to Study the Role of Connexins in Ototoxicity and Hearing Loss, Rianne Beach

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Assessing the structure-function relationships of the apolipoprotein(a) kringle IV sub-type 10 domain, Matthew J. Borrelli

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The Role of Pannexin 1 during Human Adipogenesis in vitro, Jamie Emily Ching

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Apolipoprotein(a) Secretion is Modulated by Sortilin, Proprotein Convertase Subtilisin/Kexin Type 9, and Microsomal Triglyceride Transfer Protein, Justin Clark

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Identification of Human Postnatal Progenitor Cells with Multifaceted Regenerative Functions, Tyler T. Cooper

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Integrin-linked Kinase Modulation of Melanocytic Lineage Cells, Melissa Crawford

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Pregestational Diabetes Induced Congenital Heart Defects and Coronary Artery Malformations; Mechanisms and Preventative Therapies, Anish Engineer

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Maternal nicotine exposure induces congenital heart defects in the offspring of mice, Elizabeth Greco

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Synthesis and Characterization of American Ginseng Polysaccharides Nanoparticles, Vincent Lee

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Dynamic mechanostimulation of live cells during real-time microscopy, Daniel Lorusso

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Excess NO stabilizes the luminal domain of STIM2 in a Cys-specific manner thereby regulating basal calcium homeostasis and store-operated calcium entry, Matthew Novello

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Effects of Niacin and Vitamin D on Endothelial Cell Angiogenic Function and Vascular Regeneration During Lipotoxicity, Kia Mae Peters

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The role of ATF4 in amyloid-beta-induced neuronal death., Gillian Petroff

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YAP-mediated mechanotransduction promotes fibrotic activity, Michael Racanelli

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The Purification of Human Adult Progenitor Cell Types to Promote Angiogenesis, Stephen E. Sherman

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Mapping and functional characterization of proteolytic cleavage of murine kidney injury molecule-1, Saranga Sriranganathan

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Phenotypic and Metabolic Plasticity In Canine Cellular Reprogramming, Ian C. Tobias

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Oleic Acid Attenuates Palmitic Acid-Induced Impairments in Mouse Blastocyst Development, Maisoon Dafalla Yousif

Theses/Dissertations from 2018

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The Role Of FER Kinase In Human Melanoma Growth and Invasion, Shinthujah Arulanantham

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The Characterization of Cx31 in Keratinocytes and its Link to Erythrokeratodermia Variabilis et Progressiva, Akina Au

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Clinical and Genetic Predictors of Aromatase Inhibitor-Induced Arthralgia, Adrienne Elizabeth Borrie

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The 2β Insert Perturbs Folding, Stability and Hydrophobic Exposure of Stromal Interaction Molecules, Steve Chung

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The Role of Hand1 in the Development of the Lateral Plate Mesoderm in Xenopus, Victoria A. Deveau

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A normalization circuit of attention in primate lateral prefrontal cortex, Lyndon Duong

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The Role of p66Shc in Mouse Blastocyst Development, Nicole A. Edwards

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Expression of Hepatic Cytochrome P450 Drug Metabolizing Enzymes in Diabetes and Diabetic Nephropathy, Cheng Jay Fang

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Clinical And Pharmacogenetic Determinants Of Plasma Factor Xa Inhibitor Systemic Exposure, Markus Gulilat

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Role Of The Dorsal Striatum In Learning and Decision Making, Nole M. Hiebert

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Investigating the Practical and Clinical Effectiveness of Applying Current Steering to Deep Brain Stimulation for Parkinsonian Gait Therapy, Daphne Hui

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The use of current steering during subthalamic deep brain stimulation to alleviate upper limb symptoms of Parkinson's disease, Shabna Iftikar Mohideen

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Effects of Maternal Protein Restriction on the Pulmonary Surfactant System during the Early Life and Adulthood, Reza Khazaee

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Modulation of parathyroid hormone 1 receptor signaling by extracellular nucleotides, Brandon Kim

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Heterotypic Docking Compatibility of Human Connexin 37 with Other Vascular Connexins, Nicholas Kim

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Reactive Oxygen Species and the Regulation of Cerebral Vascular Myogenic Tone, Neil Mazumdar

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Endothelial Glycocalyx Shedding in Pediatric Diabetic Ketoacidosis, Rufina Ning

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A Hierarchical Approach to Assessing the Effects of Exercise on Cognition, Alexandra Pearce

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The Role of Cholinergic Signaling in Cardiac Function, Rachel Reingold

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Investigating the role of pannexin 3 in intervertebral disc health and disease, Meaghan E. Serjeant

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The mitochondrial calcium uniporter regulator 1 (MCUR1) matrix domain is a self-associated multimer sensitive to divalent cations, Naveed Siddiqui

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Effects of G Protein Signalling Modulator 3 on Cellular Signalling, Aneta A. Surmanski

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Behavioural and Anatomical Effects of Unilateral Injection of Botulinum Neurotoxin A in the Entopeduncular Nucleus of a Parkinsonian Rat Model, Adrianna Tsang

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Drug Response And Metabolism In Crohn's Disease, Aze Wilson

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Beta-cell β1 Integrin Deficiency During Second Transition Stage Of Fetal Pancreas Development On Islet Growth, Phyo Win

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The role of TGFβ type III receptor in lung cancer cell migration and invasion, Anthony Ziccarelli

Theses/Dissertations from 2017

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The Potential Role of Cathelicidin Peptides for the Treatment of Lower Respiratory Tract Infections, Brandon John Harrison Banaschewski

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Cardiac repair post-myocardial infarction: Roles of the primary cilium and the long non-coding RNA Malat1, Jessica N. Blom

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Retinoic Acid Pathway Inhibition to Expand Human Hematopoietic Progenitor Cells with Islet Regenerative Capacity, Ruth Elgamal

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Maternal Nutrient Restriction in Pregnant Guinea Pigs and the Impact on Fetal Growth and Brain Development, Andrew Ghaly

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Hepatic Drug Metabolism, Uremic Toxins and Bacterial Composition Over Chronic Kidney Disease Progression, Emily Dee Hartjes

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Synaptic Mechanisms for the Hypothalamic-Pituitary-Adrenal Axis Activation by Prostaglandin E2, Zahra Khazaeipool

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Alternative splicing and extra-telomeric role of telomerase reverse transcriptase isoforms in human embryonic stem cells, Joohwan Kim

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The Role of OATP-Mediated Statin Transport in Pancreatic Beta Cell Function, Michelle S. Kim

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Distinct Roles of GABA(A)R Signaling in the Regulation of Two Human T lymphocyte Lines, Ying Lin

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The Metalloproteinase-Dependent Role of TIMPs in Regulation of Pulmonary Microvascular Endothelial Cell Barrier Function During Sepsis, Marcello G. Masciantonio

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Effects of Prenatal Bisphenol A Exposure on Adrenal Gland Development and Steroidogenic Function, Samantha Medwid

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Pannexins 1 and 3 in Skeletal Health and Osteoarthritis, Paxton M. Moon

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The Role of p62/SQSTM1 in TGFβ-dependent EMT and Autophagy, Evelyn Ng

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Functional Characteristics of Four Novel Lone Atrial Fibrillation-Linked Connexin40 Mutants, Mahmoud Noureldin

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Investigating The Acute Levodopa Response In Early To Advanced Parkinson’s Disease, Marcus M. Pieterman

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Liver X Receptor and Retinoid X Receptor in Cartilage Development and Homeostasis, Man-Ger Sun

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The Loss Of ATRX Creates Susceptibility To KRAS-Mediated Pancreatic Damage, Claire C. Young

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S-Nitrosylation Suppresses Stromal Interaction Molecule-1 Activation and Ameliorates Cardiomyocyte Hypertrophy, Jinhui Zhu

Theses/Dissertations from 2016

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Glycosylation on Stromal Interaction Molecule-1 Ca2+ sensing region enhances Store Operated Ca2+ Entry, Yoo Jung Choi

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New Insights into Signal Detection of the Effects of Exposures during Pregnancy, Fatma Etwel

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PDZ Protein Regulation of β-arrestin Recruitment and GPCR Trafficking, Sarah Gupta

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CAL and MAGI PDZ Protein Regulation of CRFR1 and 5-HT2AR Trafficking and Signaling, Maha Mahmoud Hammad

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The Effect of AST-120 on Hepatic Metabolism and Transport in Chronic Kidney Disease, Andrew S. Kucey

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The Mitochondrial Calcium Uniporter Is Autoregulated by Cation Binding to the β-Grasp-Like Matrix Domain, Samuel K. Lee

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Evaluating the role of intestinal transporters in fruit juice-drug interactions, Mandy MJ Li

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Evaluation of Food Effects on the Oral Pharmacokinetics of Rosuvastatin, Cheynne C. McLean

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The Biophysical Alterations to Pulmonary Surfactant during Lung Injury, Scott D. Milos

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Identification Of A Novel Interaction Between Integrin-Linked Kinase And Beta-Arrestin 1, Hannah E. Murphy-Marshman

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Corticotropin releasing factor receptor type 1 signaling in epilepsy and traumatic brain injury, V V Chakravarthi Narla

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Maternal Nutrient Restriction with Fetal Growth Restriction in Guinea Pigs Impacts Brain Development and Neuroimaging Correlates in Neonatal Offspring, Catherine Nevin

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The Role of GABA Signalling in Lung Macrophage Immune Response, Jacob W. Poirier

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Insights into the role of connexin26 and connexin30 in skin health, syndromic disease, and cutaneous wound healing, Eric R. Press

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Pharmacogenetics of Non-Motor Symptoms in Parkinson's Disease, Brian Robertson

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Putative Pore-lining Residues and Intracellular Magnesium Influence Connexin50 Unitary Gap Junction Channel Conductance, Swathy Sudhakar

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Beta blocker dialyzability and effectiveness in chronic hemodialysis patients, Alvin Tieu

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Signal Transduction Mechanisms Mediating the Regulation of Vascular G Protein-Coupled Receptors, Elena Tutunea-Fatan

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A Non-Canonical Role for Choline Acetyltransferase in Chromatin Organization and the Response to Beta-Amyloid, Warren R. Winick-Ng

Theses/Dissertations from 2015

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Septic Murine Pulmonary Microvascular Endothelial Cell Barrier Dysfunction is Regulated by Tissue Inhibitor of Metalloproteinases 3, Valerie Arpino

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KISS1R Signaling Promotes Breast Cancer Drug Resistance, Alexandra J. Blake

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Studies into the Regulation of FTO by Angiotensin II in Cardiomyocyte Hypertrophy, Kwame N. Boakye-Ansah

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Atrial Fibrillation Promotion by Intermittent Hypoxia in the Rat, Sara Bober

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TIMP3 Regulation of Macrophage Activation and Apoptosis, Michael S. Brock

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Non-Invasive Determination of Pre-Clinical Markers of Cardiovascular Diseases in Low Birth Weight and Maternal Western Diet Guinea Pig Offspring Exposed to a Postnatal Western Diet, Jacky Chiu

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The Rho GTPases Rac1, Cdc42, and RhoA Regulate APP Transport to Lysosomes and Aβ Production, Justin K. Chiu .

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Cardioprotective Role of the Cholinergic System, Mouhamed Dakroub

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Skeletal Muscle Lipid Metabolism and Markers of Insulin Resistance in Young Male Low Birth Weight Offspring in Combination With a Postnatal Western Diet, Kristyn Pamela Dunlop

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Maternal Nutrient Restriction in Pregnant Guinea Pigs Impacts Fetal-Placental Growth and Oxygenation, Alexander Elias

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Inhibition of elongation factor 1A-1 activity and hepatic lipotoxicity, Alexandra Margaret Anne Hetherington

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Engineered connexin40 variants increased docking and function of heterotypic connexin40/connexin43 gap junction channels, Arjewan Jassim

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Modulation of synaptic plasticity by hippocampal theta rhythm, Clayton Law

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Cardiomyocyte Polarity and Embryonic Heart Development: Role of Rac1, Carmen Leung

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Fibulin-3 Promotes Triple Negative Breast Cancer Cell Invasion, Michelle M. Noonan

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The CTCF Chromatin Organizer is Required for Hindlimb Development, Katherine L. Rabicki

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The Role of Connexins and Pannexins in Mammary Gland Development and Tumorigenesis, Michael K. G. Stewart

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Stability and Activity of Naturally Occurring RGS2 Variants, Patrick Stockwell