Physiology and Pharmacology Theses and Dissertations
This collection contains theses and dissertations from the Department of Physiology and Pharmacology, collected from the Scholarship@Western Electronic Thesis and Dissertation Repository
Theses/Dissertations from 2023
Characterization of A Novel Mouse Model Expressing Human 82-kDa Choline Acetyltransferase: Potential Role in Physiological and Pathological Aging, Hadir EmadElDin AlQot
Mechanisms of Impaired Efferocytosis of Synovial Macrophages in Knee Osteoarthritis, Jasika Bashal
Lipoprotein(a), Oxidized Phospholipids, and Vascular Smooth Muscle Cell Phenotype and Viability, Michael Dunphy
Upstream Regulators and Downstream Signals of YAP/TAZ in NAFLD, Chen Jun Gao
Regulation of Metalloproteinase Activity is Critical for Pulmonary Microvascular Endothelial Cell Barrier Function, Devika P. Jayawardena
Identification of Early Diagnostic and Predictive Biomarkers of Cisplatin-Induced Acute Kidney Injury Using Metabolomics, Yong Jin Lim
Adverse Effects and Pharmacokinetic Characteristics of High-Dose Glucocorticoid Treatment in Children with Rheumatic Diseases, Renee X. Pang
Metabolomic Biomarkers for Hypertensive Disease of Pregnancy, Akasham Rajagopaul
Investigating the Role of TRPV4 as a Mechanoreceptor in the Intervertebral Disc, Taylor Dominick Spence Shelton
Non-Renal Alterations of Drug Disposition in Chronic Kidney Disease, Nicholas Tonial
Effects of High Glucose on Autophagy and Apoptosis in Preimplantation Mouse Embryo Culture, Virginia Wolfe
Functional Validation of Human Multipotent Stromal Cell-secreted Islet Regenerative Proteins, Xin Yue Xie
Theses/Dissertations from 2022
Collagen IV-β1Integrin Regulation of Exocytotic Machinery in Pancreatic Beta-Cell Insulin Secretion, Malina Barillaro
Biomechanical Loading as a Driver of Synovial Neovascularization and Microvascular Dysfunction in Knee Osteoarthritis, Mckenzie Carter
Impaired Efferocytosis in Knee Osteoarthritis, Luigi M. Del Sordo
The Impact of Excess Nutrients, Fatty Acids or Glucose, on BeWo Placental Trophoblast Metabolic Function, Zachary JW Easton
MicroRNAs as Non-invasive Predictors of Preimplantation Embryo Developmental Competence, David C. Hawke
Neuronal Nitric Oxide synthase regulates the expression of EAAT4 and GAD65/67 in the murine cerebellum, Gurneet Jassal
The Effect of OATP2B1-Mediated Statin Transport on Beta Cell Dysfunction, Jihoon Kwon
The Molecular Mechanisms of Hepatic Mitochondrial Dysfunction in Growth-Restricted Offspring with Hyperlipidemia, Shelby L. Oke
Tracing the Fate of Cytokeratin 19+ Cells During Beta Cell Regeneration Stimulated by Multipotent Stromal Cell-Secreted Effectors, Nazihah Rasiwala
Exploring the effects of spinal cord stimulation for freezing of gait in parkinsonian patients, Olivia Samotus
The Effects Of Autophagy And Proteasomes On TGFβ Signalling And EMT, Charles Brandon Trelford
Roles of STIM1 Cys56 and Cys49 in Store-Operated Ca2+ Entry and Cardiac Rhythm during Myocardial Ischemia and Reperfusion, Kaiyuan Wang
Absence of Enhancer of Zeste Homolog 2 Promotes the Progression of KRAS-Driven Pancreatic Ductal Adenocarcinoma, Xiaoyi Wang
Theses/Dissertations from 2021
Exogenous Surfactant as a Delivery Vehicle for Intrapulmonary Therapeutics, Brandon J. Baer
Maternal Lifelong Western Diet Consumption Impacts Placental and Brain Development in the Term Guinea Pig Fetus, Carlene H. Cihosky
Characterization and modulatory influence of pyruvate kinase muscle isoforms 1 and 2 within the murine pluripotent continuum, Joshua G. Dierolf
Fatty Acid Regulation of the Nrf2/Keap1 Pathway During Mouse Preimplantation Embryo Development, Grace Dionne
Inwardly Rectifying Potassium Channels: Regulators of Myogenic Tone in Cerebrovascular Smooth Muscle, Jacob Fletcher
Investigating the role of interleukin-15 in post-traumatic osteoarthritis, Ermina Hadzic
Modulation of GABAA Receptor by Neurosteroids and Protein Kinases in Health and Disease, Jaymin Jeong
Effects of ergothioneine on endothelial cell and macrophage characteristics, and markers of atherosclerosis risk under high lipid conditions, Daniel Lam-Sidun
Free fatty acid treatment alters autophagy during mouse preimplantation embryo development, Zuleika C. L. Leung
Creating Tools to Study the Signaling and Function of the Adhesion Family of GPCRs, Victor M. Mirka
The effects of decellularized adipose tissue constructs on mesenchymal stromal/stem cell phenotype and pro-angiogenic secretory function., Yehia Moharrem
Uncovering the Structural Basis for Mitochondrial Calcium Uniporter Dominant Negative Beta Subunit (MCUb) Function, Megan L. Noble
Targeting CCN Proteins in the Treatment of Dermal Fibrosis, Alex Peidl
Characterizing the structural, biophysical and functional effects of S-Glutathionylation on STIM1 Ca2+ sensing, Christian Michael Sirko
Effects of Annexin A5 on Endothelial Inflammation Induced by Lipopolysaccharide-Activated Platelets and Extracellular Vesicles, Brent Jeffrey Tschirhart
Impact of Clinical and Pharmacogenetic Variables on the Risk of Fluoropyrimidine-Related Adverse Events within Ontario, Theodore J. Wigle
Theses/Dissertations from 2020
Developing a model to assess the contribution of cytokeratin 19-expressing cells during multipotent stromal cell-induced islet regeneration, Brianna Ananthan
Investigating pathways associated with intervertebral disc degeneration and back pain., Geoffrey J. Kerr
The Role of Histone Demethylases in Learning and Memory in the Mushroom Body of Drosophila melanogaster, Crystal Keung
Characterization of Mechanotransduction in Annulus Fibrosus Cells, Min Kyu M. Kim
The Role of TIMP3 in Microvascular Endothelial Cell-Extracellular Matrix Interaction and Regulation of Microvascular Barrier Function, Nidhi Kulkarni
The Role of Synovium and Synovial Macrophages in Experimental Post-Traumatic Knee Osteoarthritis, Yue Lai-Zhao
The Role of Regulator of G Protein Signaling 2 in Inflammatory Cytokine Release in Endotoxemia in Mice, Xin Tong Ma
Mushroom body-specific gene regulation by the SWI/SNF chromatin remodeling complex, Kevin CJ Nixon
The Effects of Maternal Delta-9-Tetrahydrocannabinol and Cannabidiol Exposure on Fetal Heart Development in Mice, Gregory Robinson
Mitogen Inducible Gene-6 in Joint Health and Osteoarthritis, Melina Rodrigues Bellini
Pan-Cancer Analysis of Telomerase Reverse Transcriptase (TERT) Isoforms, Mathushan Subasri
Mechanisms of beta-cell deficiency in gestational diabetes and strategies to reverse hyperglycemia, Sandra K. Szlapinski
Molecular Mechanisms Regulating the Platelet Thrombin Receptor PAR4, Pierre E. Thibeault
Regulators of Ectopic Calcification in a Mouse Model of DISH: A Multi-Omics Perspective, Matthew A. Veras
Theses/Dissertations from 2019
HEI-OC1 Cochlear Cells as an In Vitro Model to Study the Role of Connexins in Ototoxicity and Hearing Loss, Rianne Beach
Assessing the structure-function relationships of the apolipoprotein(a) kringle IV sub-type 10 domain, Matthew J. Borrelli
The Role of Pannexin 1 during Human Adipogenesis in vitro, Jamie Emily Ching
Identification of Human Postnatal Progenitor Cells with Multifaceted Regenerative Functions, Tyler T. Cooper
Integrin-linked Kinase Modulation of Melanocytic Lineage Cells, Melissa Crawford
Pregestational Diabetes Induced Congenital Heart Defects and Coronary Artery Malformations; Mechanisms and Preventative Therapies, Anish Engineer
The Secretory Pathway Calcium ATPase 2C promotes increased cytosolic calcium levels, Melissa Fenech
Maternal nicotine exposure induces congenital heart defects in the offspring of mice, Elizabeth Greco
Synthesis and Characterization of American Ginseng Polysaccharides Nanoparticles, Vincent Lee
Applications of Hair as a Record of Systemic Exposure to Cortisol, Jeffrey Matthew Levine
Dynamic mechanostimulation of live cells during real-time microscopy, Daniel Lorusso
Excess NO stabilizes the luminal domain of STIM2 in a Cys-specific manner thereby regulating basal calcium homeostasis and store-operated calcium entry, Matthew Novello
Effects of Niacin and Vitamin D on Endothelial Cell Angiogenic Function and Vascular Regeneration During Lipotoxicity, Kia Mae Peters
The role of ATF4 in amyloid-beta-induced neuronal death., Gillian Petroff
YAP-mediated mechanotransduction promotes fibrotic activity, Michael Racanelli
The Purification of Human Adult Progenitor Cell Types to Promote Angiogenesis, Stephen E. Sherman
Mapping and functional characterization of proteolytic cleavage of murine kidney injury molecule-1, Saranga Sriranganathan
Phenotypic and Metabolic Plasticity In Canine Cellular Reprogramming, Ian C. Tobias
Oleic Acid Attenuates Palmitic Acid-Induced Impairments in Mouse Blastocyst Development, Maisoon Dafalla Yousif
Theses/Dissertations from 2018
The Role Of FER Kinase In Human Melanoma Growth and Invasion, Shinthujah Arulanantham
Clinical and Genetic Predictors of Aromatase Inhibitor-Induced Arthralgia, Adrienne Elizabeth Borrie
The 2β Insert Perturbs Folding, Stability and Hydrophobic Exposure of Stromal Interaction Molecules, Steve Chung
The Role of Hand1 in the Development of the Lateral Plate Mesoderm in Xenopus, Victoria A. Deveau
A normalization circuit of attention in primate lateral prefrontal cortex, Lyndon Duong
The Role of p66Shc in Mouse Blastocyst Development, Nicole A. Edwards
Expression of Hepatic Cytochrome P450 Drug Metabolizing Enzymes in Diabetes and Diabetic Nephropathy, Cheng Jay Fang
Clinical And Pharmacogenetic Determinants Of Plasma Factor Xa Inhibitor Systemic Exposure, Markus Gulilat
Role Of The Dorsal Striatum In Learning and Decision Making, Nole M. Hiebert
The use of current steering during subthalamic deep brain stimulation to alleviate upper limb symptoms of Parkinson's disease, Shabna Iftikar Mohideen
Effects of Maternal Protein Restriction on the Pulmonary Surfactant System during the Early Life and Adulthood, Reza Khazaee
Modulation of parathyroid hormone 1 receptor signaling by extracellular nucleotides, Brandon Kim
Heterotypic Docking Compatibility of Human Connexin 37 with Other Vascular Connexins, Nicholas Kim
Reactive Oxygen Species and the Regulation of Cerebral Vascular Myogenic Tone, Neil Mazumdar
Endothelial Glycocalyx Shedding in Pediatric Diabetic Ketoacidosis, Rufina Ning
A Hierarchical Approach to Assessing the Effects of Exercise on Cognition, Alexandra Pearce