Paediatrics Publications

Title

Change in hematologic indices over time in pediatric inflammatory bowel disease treated with azathioprin

Document Type

Article

Publication Date

12-1-2010

Journal

Drugs in R and D

Volume

10

Issue

4

First Page

213

Last Page

217

URL with Digital Object Identifier

10.2165/11539930-000000000-00000

Abstract

Azathioprine leads to changes in mean corpuscular volume (MCV) and white blood cell (WBC) indices reflecting efficacy or toxicity. Understanding the interactions between bone marrow stem cells and azathioprine could highlight abnormal response patterns as forerunners for hematologic malignancies. This study gives a statistical description of factors influencing the relationship between MCV and WBC in children with inflammatory bowel disease treated with azathioprine. We found that leukopenia preceded macrocytosis. Macrocytosis is therefore not a good predictor of leukopenia. Further studies will be necessary to determine the subgroup of patients at increased risk of malignancies based on bone marrow response. © 2010 Soman et al., publisher and licensee Adis Data Information BV.

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