Paediatrics Publications
Title
In vitro and in vivo activity of voriconazole and benznidazole combination on trypanosoma cruzi infection models
Document Type
Article
Publication Date
11-1-2020
Journal
Acta Tropica
Volume
211
First Page
105606
URL with Digital Object Identifier
https://doi.org/10.1016/j.actatropica.2020.105606
Abstract
Combination therapy has been proposed as an ideal strategy to reduce drug toxicity and improve treatment efficacy in Chagas disease. Previously, we demonstrated potent in vivo anti-Trypanosoma cruzi activity of voriconazole. In this work, we aimed to study the synergistic effect of voriconazole (VCZ) and benznidazole (BZ) both in vitro and in vivo models of T. cruzi infection using the Tulahuen strain. Combining VCZ and BZ at fixed concentrations, the inhibitory concentration 50% (IC
