Paediatrics Publications
Document Type
Article
Publication Date
2-9-2018
Journal
Indian Journal of Nephrology
Volume
28
Issue
1
First Page
73
Last Page
75
URL with Digital Object Identifier
https://doi.org/10.4103/ijn.IJN_310_16
Abstract
Eculizumab is the therapy of choice for patients with atypical hemolytic uremic syndrome (aHUS). Dosing recommendations stem from two trials: one retrospective trial (19 children and 5 infants) and one prospective trial (22 patients and 5 infants). This case report highlights the need for more precise dosing recommendations in children, particularly in infants, and for smaller vials of the medication to facilitate more precise dosing. Such changes would ensure that adverse events are minimized and that the children with aHUS who are treated with eculizumab experience an optimal clinical response.
Citation of this paper:
Kobrzynski M, Wile B, Huang S S, Filler G. Eculizumab dosing in infants. Indian J Nephrol 2018;28:73-5
Notes
Article originally published in Indian Journal of Nephrology, Vol. 28(1).