Paediatrics Publications
Title
Role of Endothelium in Doxorubicin-Induced Cardiomyopathy
Document Type
Article
Publication Date
12-1-2018
Journal
JACC: Basic to Translational Science
Volume
3
Issue
6
First Page
861
Last Page
870
URL with Digital Object Identifier
10.1016/j.jacbts.2018.06.005
Abstract
The clinical use of doxorubicin in cancer is limited by cardiotoxic effects that can lead to heart failure. Whereas earlier work focused on the direct impact of doxorubicin on cardiomyocytes, recent studies have turned to the endothelium, because doxorubicin-damaged endothelial cells can trigger the development and progression of cardiomyopathy by decreasing the release and activity of key endothelial factors and inducing endothelial cell death. Thus, the endothelium represents a novel target for improving the detection, management, and prevention of doxorubicin-induced cardiomyopathy.
COinS