Paediatrics Publications

Title

Population PK modelling and simulation based on fluoxetine and norfluoxetine concentrations in milk: a milk concentration-based prediction model

Document Type

Article

Publication Date

10-1-2014

Journal

British journal of clinical pharmacology

Volume

78

Issue

4

First Page

918

Last Page

928

URL with Digital Object Identifier

10.1111/bcp.12409

Abstract

AIMS: Population pharmacokinetic (pop PK) modelling can be used for PK assessment of drugs in breast milk. However, complex mechanistic modelling of a parent and an active metabolite using both blood and milk samples is challenging. We aimed to develop a simple predictive pop PK model for milk concentration-time profiles of a parent and a metabolite, using data on fluoxetine (FX) and its active metabolite, norfluoxetine (NFX), in milk.

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