Paediatrics Publications

Title

Retinoic acid and the development of the endoderm

Document Type

Article

Publication Date

6-1-2015

Journal

Journal of Developmental Biology

Volume

3

Issue

2

First Page

25

Last Page

56

URL with Digital Object Identifier

10.3390/jdb3020025

Abstract

Retinoic acid (RA) is an important signaling molecule in the development of the endoderm and an important molecule in protocols used to generate endodermal cell types from stem cells. In this review, we describe the RA signaling pathway and its role in the patterning and specification of the extra embryonic endoderm and different endodermal organs. The formation of endoderm is an ancient evolutionary feature and RA signaling appears to have coevolved with the vertebrate lineage. Towards that end, we describe how RA participates in many regulatory networks required for the formation of extraembryonic structures as well as the organs of the embryo proper.

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