Paediatrics Publications

Title

Non-canonical functions of the RB protein in cancer

Document Type

Article

Publication Date

7-1-2018

Journal

Nature Reviews Cancer

Volume

18

Issue

7

First Page

442

Last Page

451

URL with Digital Object Identifier

10.1038/s41568-018-0008-5

Abstract

The canonical model of RB-mediated tumour suppression developed over the past 30 years is based on the regulation of E2F transcription factors to restrict cell cycle progression. Several additional functions have been proposed for RB, on the basis of which a non-canonical RB pathway can be described. Mechanistically, the non-canonical RB pathway promotes histone modification and regulates chromosome structure in a manner distinct from cell cycle regulation. These functions have implications for chemotherapy response and resistance to targeted anticancer agents. This Opinion offers a framework to guide future studies of RB in basic and clinical research.

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