Paediatrics Publications

Title

Integrin-linked kinase: A Scaffold protein unique among its ilk

Document Type

Article

Publication Date

6-1-2011

Journal

Journal of Cell Communication and Signaling

Volume

5

Issue

2

First Page

81

Last Page

83

URL with Digital Object Identifier

10.1007/s12079-011-0124-4

Abstract

Integrin-linked kinase (ILK) is a scaffolding protein with central roles in tissue development and homeostasis. Much debate has focused on whether ILK is a bona fide or a pseudo- kinase. This aspect of ILK function has been complicated by the large volumes of conflicting observations obtained from a wide variety of experimental approaches, from in vitro models, to analyses in invertebrates and in mammals. Key findings in support or against the notion that ILK is catalytically active are summarized. The importance of ILK as an adaptor protein is well established, and defining its role as a signaling hub will be the next key step to understand its distinct biological roles across tissues and species. © 2011 The International CCN Society.

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