Current Issues in Transplantation: Proceedings of the XVI Annual Conference of Indian Society of Organ Transplantation
Using a syngeneic islet transplantation model system we have showed that in autoimmune type 1 diabetes transplanted islets are destroyed by the host immune system unless the transplanted islets lack class I major histocompatibility complex (MHC) molecules. Alternatively, immunomodulation of the host by induction of regulatory T cells prevented the destruction of autologous islet graft. We conclude that these approaches will allow successful transplantation of autologous islets derived from the host by stem cell or other technology without immunosuppression to reverse autoimmune type 1 diabetes.
Citation of this paper:
Singh B. Role of MHC antigens and Immunoregulation in Graft Survival. In Current Issues in Transplantation: Proceedings of the XVI Annual Conference of Indian Society of Organ Transplantation (ISOT-2005). Jaipur, Rajasthan, India. Ed. L.C. Sharma, Chapter 8, pp.109-114, 2007