Title
T-cell Anergy and Altered T-cell Receptor Signaling: Effects on Autoimmune Disease
Document Type
Article
Publication Date
10-1998
Journal
Immunology Today
Volume
19
Issue
10
First Page
468
Last Page
473
URL with Digital Object Identifier
10.1016/S0167-5699(98)01326-7
Abstract
Immunological self-tolerance can be acquired by several mechanisms, including the induction of anergy in autoreactive T cells. In this sense, anergy is predictably advantageous for the immune system. Here, Konstantin Salojin and colleagues present an alternative view that the induction of anergy in regulatory T cells may be harmful to the host and elicit autoimmune disease.
