Electronic Thesis and Dissertation Repository


Master of Clinical Science




Brackstone,Muriel MD, PhD, FRCSC

2nd Supervisor

Chris Doherty



We aimed to investigate the cost-effectiveness of bilateral prophylactic mastectomy (BPM) with and without different reconstruction for the purpose of determining which strategies represent value for money. We developed a decision analytic model to project the lifetime clinical and economic consequences of different strategies. The decision model was parameterized using 10-year follow up and cost data from Ontario administrative health databases and Ontario Cancer registry. Compared to the organized screening-based strategy, surgical strategies ranged from being more effective and cost-saving and up to being associated with an incremental cost effectiveness ratio (ICER) of $63,010 per quality-adjusted life year (QALY) gained, with BPM with immediate one-stage acellular dermal matrix (ADM)-assisted implant breast reconstruction having the greatest incremental QALY of 1.157 and lowest ICER of $9,615. BPM with immediate one-stage ADM-assisted implant breast reconstruction is the most cost-effective strategy and appears to offer the highest value for money.

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Surgery Commons