Electronic Thesis and Dissertation Repository


Master of Engineering Science


Chemical and Biochemical Engineering


Jesse Zhu


Although Mesalazine (5-ASA) demonstrates huge popularity in treating inflammatory bowel disease (IBD) due to its local effect on intestinal and colonic mucosa, it still demands more accurate and effective delivery of 5-ASA. As pellets embrace various technological and therapeutic advantages over the single-unit dosage form, this study aims at developing and optimizing the drug-loading and coating processes of 5-ASA pellets with a novel rotating fluidized bed. Powder layering and powder coating techniques, which are the same in essence, were applied in the drug-loading and coating processes, respectively. Three different coatings of 5-ASA pellets were achieved, resulting in extended, delayed and extended-delayed release, aiming at prolonging 5-ASA release time, targeting 5-ASA to colon region and the combination of the first two, respectively. Overall, this project offers a promising approach to delivering 5-ASA to specific colon sites.

Available for download on Saturday, January 01, 2022