Electronic Thesis and Dissertation Repository


Master of Science


Medical Biophysics


Stephen Lownie, MD


Hypothermia is a well-established neuroprotectant. Selective hypothermia to the ischemic area may eliminate side effects while improving induction time. We studied the effect of selective hypothermia on stroke volumes in adult domestic swine. Under general anesthesia, one MCA was occluded transcranially for 3 hours followed by 3 hours of reperfusion. In half the animals, hypothermia was induced during reperfusion via a dual-lumen balloon occlusion catheter placed in the carotid ipsilateral to the ischemic region. Following reperfusion, the animals were sacrificed. Brain MRI and histology were evaluated blinded to the intervention. In a series of animals, the mean temperature achieved was 26.5C. Mean time from start of perfusion to moderate hypothermia (< 30 C) was 25.4 minutes. Mean stroke volumes were reduced by 38.4-44.2% in the hypothermia group (p=0.292). Selective moderate hypothermia can be rapidly induced using endovascular technology. A promising reduction in stroke volumes is seen. Further study is warranted.

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