Total versus partial splenectomy in pediatric hereditary spherocytosis: a systematic review and meta-analysis

Authors

Leonardo Guizzetti, Western UniversityFollow

Document Type

Article

Publication Date

6-14-2016

Journal

Pediatric Blood & Cancer

Volume

63

Issue

10

First Page

1713

Last Page

1722

URL with Digital Object Identifier

10.1002/pbc.26106

Abstract

To compare the clinical effectiveness of total (TS) or partial (PS) splenectomy in pediatric hereditary spherocytosis, a systematic review and meta-analysis was performed (PROSPERO registration CRD42015030056). There were 14 observational studies comparing pre- and post- operative hematologic parameters. Secondary outcomes include in-hospital infections, surgical complications, symptomatic recurrence and biliary disease. TS is more effective than PS to increase hemoglobin (3.6 g/dL vs 2.2 g/dL) and reduce reticulocytes (12.5% vs 6.5%) after one year; outcomes following PS are stable for at least 6 years. There were no cases of overwhelming post-splenectomy sepsis. A population-based patient registry is needed for long-term follow-up.

Notes

PMID: 27300151

Citation of this paper:

Guizzetti, L. (2016), Total versus partial splenectomy in pediatric hereditary spherocytosis: A systematic review and meta-analysis. Pediatr Blood Cancer, 63: 1713–1722. doi:10.1002/pbc.26106