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In this era of reading as a priority, research has indicated that children with Down syndrome (DS) can indeed learn to read, attaining functional levels of literacy and beyond. Families of children with DS are also increasingly advocating for reading instruction for their children. However, few studies have examined what beginning educators know about reading and DS. This study explored the knowledge and perceptions of pre-service special educators about the reading needs and abilities of children with DS. Participants were 225 university students, enrolled in special education teaching credential programs in two southern California universities, who completed a survey designed to assess their knowledge of teaching reading to children with DS, as well as to describe their approach to reading instruction with these students. Results showed promising knowledge on the part of these future teachers, but also highlight the importance of adequate teacher preparation in teaching reading to children with DS.