Date of Award
2007
Degree Type
Thesis
Degree Name
Master of Science
Program
Epidemiology and Biostatistics
Supervisor
Dr. Jeffrey Mahon
Abstract
Introduction Delayed graft function (DGF) in a kidney recipient is associated with allograft dysfunction over time. Whether being a mate to a DGF recipient is associated with allograft dysfunction at one-year following transplantation is less well described, and the focus of this thesis. Methods Using a retrospective cohort design we studied the mean change in glomerular filtration rate (GFR) at one-year in twenty-six mates to DGF recipients (exposure group) and twenty-nine mates to non-DGF recipients (control group). Results The exposure group had a mean change in GFR of-11.2 ml/min compared to -0.4 ml/min in the control group. In a multivariable analysis, this difference was statistically significant (p-value=0.025). Conclusion In this study, being a mate to a DGF recipient was associated with allograft dysfunction at one-year following transplantation. The development of strategies aimed at preserving allograft function in this high-risk group is warranted.
Recommended Citation
Johnson, John Francis, "FATE OF THE MATE: THE INFLUENCE OF DELAYED GRAFT FUNCTION IN KIDNEY TRANSPLANTATION ON THE MATE RECIPIENT" (2007). Digitized Theses. 5124.
https://ir.lib.uwo.ca/digitizedtheses/5124