Date of Award
2011
Degree Type
Thesis
Degree Name
Master of Engineering Science
Program
Chemical and Biochemical Engineering
Supervisor
Dr. Sohrab Rohani
Second Advisor
Dr. Hossein Kazemian
Abstract
MIL-53(Fe) was synthesized by conventional electric (CE) heating, and by ultrasound (UTS) and microwave (MW) irradiation to develop rapid and energy efficient synthesis techniques. MW and UTS conditions rapidly produced small and highly crystalline materials in 10 and 7 minutes, respectively. The energy consumption of UTS and MW irradiation were less than CE heating, confirming that these two technologies are quicker, more efficient and greener alternatives to conventional synthesis methods. The use of MIL-53(Fe), MIL-101, and SBA-15 as matrices for the adsorption and in vitro drug delivery of acetaminophen, progesterone, and stavudine was studied. An initial burst release from both MIL-53(Fe) and MIL-101 was followed by a slow diffusion-controlled release, which occurred for up to 6 and 5 days, respectively. Complete release from SBA-15 occured in as quickly as 30 minutes as a result of rapid drug dissolution and diffusion out of the pores.
Recommended Citation
Gordon, Jeffrey Kenneth, "POROUS NANOMATERIALS AS CONTROLLED DRUG DELIVERY SYSTEMS" (2011). Digitized Theses. 3473.
https://ir.lib.uwo.ca/digitizedtheses/3473