Title

Genetic manipulation of lactate metabolism to regulate memory and Alzheimer's disease pathogenesis

Authors and Researchers

BrainsCAN , Western University
Robert Cumming, Western University
Robert Bartha, Western University
Tim Scholl, Western University

Files

Description

Our project will attempt to determine the relative importance of astrocyte or neuronal directed lactate generation on memory by modifying mouse models to either suppress or overexpress the lactate producing enzyme in either cell type. Using these newly created transgenic mouse models, we aim to understand the processes of production and utilization of lactate and its effect on memory and cognition in health and in AD across the lifespan. The outcome of our study may lead to entirely new clinical approaches to treating cognitive and neurodegenerative disorders via drugs which alter lactate metabolism.

Publication Date

2018

Publisher

BrainsCAN

City

London

Keywords

Alzheimer's disease, Memory

Disciplines

Neurosciences

Funding

Funding Program

BrainsCAN Accelerator Grant: Stimulus

Additional BrainsCAN Support

Imaging Core Rodent Cognition Core

Notes

Western Faculty, Group or Institution

Department of Biology, Faculty of Science

Creative Commons License

This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.