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It has recently been shown that astrocytes play a leading role in a particular aspect of memory known as 'pattern separation' - differentiating between similar experiences or episodes in memory (say, recalling where you parked your car today compared to where you parked it yesterday). Pattern separation is disrupted in a wide variety of diseases of the brain so it is of considerable interest to memory researchers.
We have already shown in a small pilot study that we can improve pattern separation with selective manipulation of astrocytes in a specific brain region. In this project, we will attempt to demonstrate a clear relationship between astrocyte signalling and performance at pattern separation, and propose the underlying mechanisms of this influence of astrocytes on pattern separation.
Memory, Novel neuroscience / neuroimaging techniques, Touchscreens
Additional BrainsCAN Support
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