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Description
It has recently been shown that astrocytes play a leading role in a particular aspect of memory known as 'pattern separation' - differentiating between similar experiences or episodes in memory (say, recalling where you parked your car today compared to where you parked it yesterday). Pattern separation is disrupted in a wide variety of diseases of the brain so it is of considerable interest to memory researchers.
We have already shown in a small pilot study that we can improve pattern separation with selective manipulation of astrocytes in a specific brain region. In this project, we will attempt to demonstrate a clear relationship between astrocyte signalling and performance at pattern separation, and propose the underlying mechanisms of this influence of astrocytes on pattern separation.
Publication Date
2018
Publisher
BrainsCAN
City
London
Keywords
Memory, Novel neuroscience / neuroimaging techniques, Touchscreens
Disciplines
Neurosciences
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.
Notes
Western Faculty, Group or Institution
Department of Physiology & Pharmacology, Schulich School of Medicine & Dentistry