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Description

Cognitive impairments in early Parkinson's disease are known to be linked to complex changes in the dopamine system within the brain. For example, dopamine-producing neurons in one key region of the brain are significantly degenerated, but those in another are spared. Dopamine-replacement therapy (DRT) has been pursued and it has produced significant improvements in certain cognitive functions - unfortunately it also produced significant impairments in others.

Publication Date

2018

Publisher

BrainsCAN

City

London

Keywords

Parkinson's disease, MRI, fMRI

Disciplines

Neurosciences

Funding

Funding Program

BrainsCAN Accelerator Grant: Stimulus

Additional BrainsCAN Support

Imaging Core

Notes

Western Faculty, Group or Institution

Department of Clinical Neurological Sciences, Schulich School of Medicine & Dentistry

Creative Commons License

Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

Relating functional and structural signatures of Parkinson’s disease to changes in dopamine signalling: A PET/fMRI study

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