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Description

We have generated two mouse models in which we can control the Gq and Gisignalling in microglia during specific periods of brain development so we can explore the mechanisms behind abnormal microglial function.

Using our mouse models, we can stimulate these signalling pathways during the critical period of postnatal brain development to understand whether they impact adult cognition by influencing normal synaptic pruning. Mouse models of autism show issues with social memory, attention, sociability and hyperactivity. We will therefore assess those behaviors in our mouse models to determine if any autism-like behaviours are present.

Publication Date

2018

Publisher

BrainsCAN

City

London

Keywords

Mental health, Memory, Mood and emotion and social behaviour

Disciplines

Neurosciences

Funding

Funding Program

BrainsCAN Accelerator Grant: Stimulus

Additional BrainsCAN Support

Rodent Cognition Core

Notes

Western Faculty, Group or Institution

Robarts Research Institute,
Schulich School of Medicine & Dentistry

Creative Commons License

Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

Role of microglia signaling in brain circuit development and cognition

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Neurosciences Commons

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