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We have generated two mouse models in which we can control the Gq and Gisignalling in microglia during specific periods of brain development so we can explore the mechanisms behind abnormal microglial function.
Using our mouse models, we can stimulate these signalling pathways during the critical period of postnatal brain development to understand whether they impact adult cognition by influencing normal synaptic pruning. Mouse models of autism show issues with social memory, attention, sociability and hyperactivity. We will therefore assess those behaviors in our mouse models to determine if any autism-like behaviours are present.
Memory, Mental health, Mood and emotion and social behaviour
Additional BrainsCAN Support
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