Vitamin D-related changes in intracranial volume in older adults: a quantitative neuroimaging study.

Authors

Cedric Annweiler, Department of Geriatric Medicine, Angers University Hospital; UPRES EA4638, University of Angers, UNAM, France; Research Center on Autonomy and Longevity (CeRAL), Angers, France; Robarts Research Institute, Department of Medical Biophysics, Schulich School of Medicine and Dentistry, the University of Western Ontario, London, ON, CanadaFollow
Robert Bartha, Robarts Research Institute, Department of Medical Biophysics, Schulich School of Medicine and Dentistry, the University of Western Ontario, London, ON, Canada
Sandy Goncalves, Robarts Research Institute, Department of Medical Biophysics, Schulich School of Medicine and Dentistry, the University of Western Ontario, London, ON, Canada
Spyridon N Karras, Unit of Reproductive Endocrinology, First Department of Obstetrics and Gynecology, Medical School, Aristotle University of Thessaloniki, Greece
Pascal Millet, Aix Marseille University, NICN, CNRS UMR 7259, Center for Clinical Investigations in Biotherapy, Marseille, France
Francois Féron, Aix Marseille University, NICN, CNRS UMR 7259, Center for Clinical Investigations in Biotherapy, Marseille, France
Olivier Beauchet, Department of Geriatric Medicine, Angers University Hospital; UPRES EA4638, University of Angers, UNAM, France; Research Center on Autonomy and Longevity (CeRAL), Angers, France; Biomathics, France

Document Type

Article

Publication Date

3-1-2015

Journal

Maturitas

Volume

80

Issue

3

First Page

312

Last Page

317

URL with Digital Object Identifier

10.1016/j.maturitas.2014.12.011

Abstract

OBJECTIVES: Vitamin D is involved in skeletal and brain health. Recently, serum 25-hydroxyvitamin D (25OHD) concentration was found to be inversely correlated with intracranial volume in younger adults. Since hypovitaminosis D is most common in older adults, our objective was to determine whether this inverse correlation between 25OHD concentration and intracranial volume also occurred in older adults.

STUDY DESIGN: Cross-sectional study.

MAIN OUTCOME MEASURES: One hundred and ten Caucasian older community-dwellers (mean, 71.7±5.7 years; 45.5% female) received a blood test and an MRI of the brain at the same period. The intracranial volume and the subvolumes of cerebrospinal fluid, total brain, infratentorial brain, supratentorial brain, total white matter, total gray matter, cortical gray matter and subcortical gray matter were measured using FreeSurfer volumetry on T1-weighted images. Vitamin D insufficiency was defined as serum 25OHD<50nmol/L. Age, gender, body mass index, education level, use of vitamin D supplements, season of evaluation, serum concentrations of calcium and thyroid stimulating hormone were used as covariables in the analysis.

RESULTS: We found that participants with vitamin D insufficiency (n=41) had greater intracranial volume than those without (1555.0±1379.2cm(3) versus 1488.0±167.4cm(3), P=0.033). Serum 25OHD concentration was cross-sectionally associated with decreased intracranial volume in mm(3) (unadjusted β=-1194.4, P=0.028), even after adjustment for covariables (adjusted β=-994.3, P=0.048). We found an inverse correlation of serum 25OHD with intracranial volume (r=-0.21, P=0.028) and the volume of white matter (r=-0.20, P=0.033). The other subvolumes did not correlate with serum 25OHD concentration.

CONCLUSIONS: Serum 25OHD concentration was independently and inversely associated with intracranial volume in older adults.

Notes

This article is paywalled - seek access through your institution's library