Bone and Joint Institute

Title

Versatile strained alkyne modified water-soluble AuNPs for interfacial strain promoted azide-alkyne cycloaddition (I-SPAAC)

Document Type

Article

Publication Date

4-7-2014

Journal

Journal of Materials Chemistry B

Volume

2

Issue

13

First Page

1764

Last Page

1769

URL with Digital Object Identifier

10.1039/c3tb21799j

Abstract

Versatile water- and organic solvent-soluble AuNPs that incorporate an interfacial strained alkyne capable of efficient pour and mix strain promoted interfacial cycloadditions with azide partners have been synthesized and carefully characterized for the first time. The use of XPS to quantitate the loading of the strained alkyne on the AuNPs is noteworthy. The reactivity towards the interfacial strain promoted azide-alkyne cycloaddition reaction was demonstrated by using azide-decorated polymersomes as bioorthogonal reaction partners. © 2014 The Royal Society of Chemistry.

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