Design of tissue-specific extracellular matrix composite hydrogels for adipose-derived stem/stromal cell (ASC) delivery
Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
© 2019 Omnipress - All rights reserved. Statement of Purpose: There is a compelling need to develop hydrogel cell delivery systems that incorporate tissue specific ECM as a cell instructive component, to enhance survival and direct cell function. Building from our previous work supporting the potential of composite bioscaffolds incorporating decellularized adipose tissue (DAT) within methacrylated chondroitin sulphate (MCS) hydrogels,1,2 the current study focused on investigating the effects of incorporating tissue-specific ECM sourced from DAT or decellularized trabecular bone (DTB) on encapsulated human ASCs. We hypothesized that incorporating tissue-specific ECM would provide an inductive microenvironment that would promote lineage-specific ASC differentiation.