A comparison of serologic reactivity among SLE patients with or without anti-Ro (SS-A) antibodies

Authors

D. A. Bell, London Health Sciences Centre
R. Komar, London Health Sciences Centre
W. B. Chodirker, London Health Sciences Centre
J. Block
E. Cairns

Document Type

Article

Publication Date

12-1-1984

Journal

Journal of Rheumatology

Volume

11

Issue

3

First Page

315

Last Page

317

Abstract

The serum from 112 patients with systemic lupus erythematosus (SLE) was examined to compare serologic reactivity among anti-Ro positive and anti-Ro negative patients. While hypergammaglobulinemia, rheumatoid factor (RF) and elevated Clq binding were significantly more frequent among the anti-Ro positive group there was no increase in the frequency of anti-dsDNA antibody measured by the Farr assay or antibodies to ssDNA, dsDNA, poly dG ̇ poly dC, poly (dA-dT) and cardiolipin measured by ELISA. Patients with the highest levels of anti-DNA antibody by the Farr assay did not have any increased frequency of anti-Ro antibodies. We concluded that anti-RO and anti-DNA antibodies are independently regulated. The frequent occurrence of RF in anti-Ro positive SLE patients may provide a useful screening assay for this autoantibody among pregnant SLE patients.

Notes

Not available online from the journal