Three-dimensional ultrasound quantification of intensive statin treatment of carotid atherosclerosis
Ultrasound in Medicine & Biology
URL with Digital Object Identifier
This study was designed to evaluate 3-D ultrasound (3DUS)-derived vessel wall volume (VWV), a 3-D measurement of the carotid artery intima and media, including atherosclerotic plaque, in patients enrolled in a randomized placebo-controlled three-month study of intensive atorvastatin treatment. Thirty-five subjects with carotid stenosis >60% who provided written informed consent and completed a randomized, double-blind, placebo-controlled study were evaluated at baseline and at three months after receiving either 80 mg atorvastatin (16 subjects, nine male, mean age 68+/-8.6 y) or placebo (19 subjects, 15 male, mean age 70+/-9.4 y) daily. 3DUS images were acquired and 3DUS VWV was manually segmented by a single observer. Individual lumen and wall segmentation contours were also used to generate carotid atherosclerosis thickness difference maps by establishing correspondence between points along the vessel wall and lumen segmentation contour surfaces, and digitally subtracting registered baseline and follow-up thickness maps. 3DUS VWV increased by 70+/-140 mm(3) (+4.9+/-10.3%) in the placebo group and decreased by 30+/-110 mm(3) (-1.4+/-7.7%) in the atorvastatin group (p
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.
This is an author accepted manuscript of an article initially published by Elsevier in Ultrasound in Medicine and Biology. The final published version is available at: https://doi.org/10.1016/j.ultrasmedbio.2009.05.017