Rapid single-breath hyperpolarized noble gas MRI-based biomarkers of airspace enlargement
Journal of Magnetic Resonance Imaging : JMRI
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BACKGROUND: Multi-b diffusion-weighted hyperpolarized-gas MRI measures pulmonary airspace-enlargement using apparent diffusion coefficients (ADCs) and mean-linear-intercepts (L
PURPOSE: To develop single-breath 3D multi-b diffusion-weighted
STUDY TYPE: Prospective.
SUBJECTS: We evaluated 12 participants, including nine subjects (mean age = 69 ± 9) who were included in the retrospective experiment and three chronic pulmonary obstruction disease (COPD) patients (mean age = 81 ± 6) who participated in the prospective study.
FIELD STRENGTH: A whole-body 3 T 2D/3D fast gradient recall echo (FGRE) sequence.
STATISTICAL TESTS: Multivariate analysis of variance, independent t-tests and voxel-by-voxel basis difference test.
RESULTS: For the retrospectively undersampled
DATA CONCLUSION: This is a proof-of-concept demonstration of accelerated (7×) morphometry that shows that less cost- and time-efficient multibreath methods that lead to variability and patient fatigue may be avoided in the future.
LEVEL OF EVIDENCE: 2 Technical Efficacy: Stage 5 J. Magn. Reson. Imaging 2018.
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This is the peer reviewed version of the following article: A. Westcott, F. Guo, G. Parraga & A. Ouriadov. (2018). Rapid single-breath hyperpolarized noble gas MRI-based biomarkers of airspace enlargement, 49(6): 1713-1722, which has been published in final form at https://doi.org/10.1002/jmri.26574. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.