Ultrashort echo time MRI biomarkers of asthma

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Journal of Magnetic Resonance Imaging : JMRI





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PURPOSE: To develop and assess ultrashort echo-time (UTE) magnetic resonance imaging (MRI) biomarkers of lung function in asthma patients.

MATERIALS AND METHODS: Thirty participants including 13 healthy volunteers and 17 asthmatics provided written informed consent to UTE and pulmonary function tests in addition to hyperpolarized-noble-gas 3T MRI and computed tomography (CT) for asthmatics only. The difference in MRI signal-intensity (SI) across four lung volumes (full-expiration, functional-residual-capacity [FRC], FRC+1L, and full-inspiration) was determined on a voxel-by-voxel basis to generate dynamic proton-density (DPD) maps. MRI ventilation-defect-percent (VDP), UTE SI, and DPD values as well as CT radiodensity were determined for whole lung and individual lobes.

RESULTS: Mean SI at full-expiration (P < 0.01), FRC (P < 0.05), and DPD (P < 0.01) were greater in healthy volunteers compared to asthmatics. In asthmatics, UTE SI at full-expiration and DPD were correlated with FEV

CONCLUSION: In patients with asthma, UTE SI and dynamic proton-density were related to pulmonary function measurements, whole lung and lobar VDP, as well as CT radiodensity. Thus, UTE MRI biomarkers may reflect ventilation heterogeneity and/or gas-trapping in asthmatics using conventional equipment, making this approach potentially amenable for clinical use.

LEVEL OF EVIDENCE: 2 J. Magn. Reson. Imaging 2017;45:1204-1215.


This is the peer reviewed version of the following article: K Sheikh, F Guo, DPI Capaldi, A Ouriadov, RL Eddy, S Svenningsen, G Parraga for the Canadian Respiratory Research Network (2017). Ultrashort echo time MRI biomarkers of asthma, 45(4): 1204-1215, which has been published in final form at https://doi.org/10.1002/jmri.25503. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.

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